LYN

Tyrosine-protein kinase Lyn ;
Lck/Yes-related novel protein tyrosine kinase ;
V-yes-1 Yamaguchi sarcoma viral related oncogene homolog ;
p53Lyn ;
p56Lyn ;

catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SH3 domain.,subunit:Interacts with phosphorylated LIME1 and with CD79A upon BCR activation. Interacts with Epstein-Barr virus LMP2A. Interacts with TGFB1I1. Interaction, via the SH2 and SH3, domains with MUC1 is stimulated by IL7 and, the subsequent phosphorylation increases the binding between MUC1 and CTNNB1/beta-catenin. Interacts with PPP1R15A via the SH3 domain.,tissue specificity:Expressed in primary neuroblastoma tumors.,

response to acid, cell activation, cytokine production, histamine secretion, regulation of protein amino acid phosphorylation, positive regulation of protein amino acid phosphorylation, immune effector process, activation of immune response, cell activation during immune response, myeloid leukocyte activation, myeloid cell activation during immune response, histamine production during acute inflammatory response, leukocyte activation during immune response, immune response-activating cell surface receptor signaling pathway, histamine secretion during acute inflammatory response, leukocyte mediated immunity, myeloid leukocyte mediated immunity, mast cell mediated immunity, immune system development, acute inflammatory response, production of molecular mediator of acute inflammatory response, histamine secretion by mast cell, positive regulation of immune system process, immune response-activating signal transduction, immune response-regulating signal transduction, immune response-regulating cell surface receptor signaling pathway, generation of a signal involved in cell-cell signaling, protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, exocytosis, defense response,inflammatory response, immune response, response to DNA damage stimulus, response to sterol depletion, cell surface receptor linked signal transduction, intracellular signaling cascade, cell-cell signaling, protein localization,positive regulation of cell proliferation, response to temperature stimulus, protein secretion, response to heat,response to wounding, response to abiotic stimulus, response to toxin, response to endogenous stimulus, response to hormone stimulus, response to carbohydrate stimulus, hormone transport, positive regulation of signal transduction, response to extracellular stimulus, glial cell differentiation, response to organic substance, response to organic nitrogen, regulation of calcium ion transport into cytosol, positive regulation of phosphorus metabolic process,positive regulation of macromolecule metabolic process, regulation of protein kinase cascade, positive regulation of cell communication, positive regulation of cell development, positive regulation of protein kinase cascade, regulation of hormone levels, regulation of metal ion transport, oligodendrocyte development, regulation of gliogenesis, positive regulation of gliogenesis, response to organic cyclic substance, response to amine stimulus, protein transport, amine transport, vesicle-mediated transport, phosphorylation, peptidyl-tyrosine phosphorylation, peptidyl-tyrosine modification, regulation of phosphate metabolic process, glial cell development, hemopoiesis, myeloid cell differentiation, erythrocyte differentiation, regulation of protein modification process, positive regulation of protein modification process, cellular response to extracellular stimulus, regulation of cellular protein metabolic process,positive regulation of cellular protein metabolic process, regulation of homeostatic process, response to insulin stimulus, secretion by cell, cellular response to stress, erythrocyte homeostasis, cellular response to heat, gliogenesis,regulation of cell proliferation, regulation of phosphorylation, positive regulation of phosphorylation, response to drug,regulation of tyrosine phosphorylation of STAT protein, positive regulation of tyrosine phosphorylation of STAT protein,homeostatic process, response to amino acid stimulus, regulation of ion transport, leukocyte degranulation, mast cell degranulation, response to peptide hormone stimulus, regulated secretory pathway, establishment of protein localization, leukocyte activation, mast cell activation, positive regulation of cell differentiation, positive regulation of phosphate metabolic process, regulation of JAK-STAT cascade, positive regulation of JAK-STAT cascade, hormone secretion, secretion, hemopoietic or lymphoid organ development, positive regulation of response to stimulus,response to axon injury, oligodendrocyte differentiation, homeostasis of number of cells, cytokine secretion, regulation of peptidyl-tyrosine phosphorylation, positive regulation of peptidyl-tyrosine phosphorylation, regulation of neurogenesis, positive regulation of neurogenesis, positive regulation of immune response, antigen receptor-mediated signaling pathway, B cell receptor signaling pathway, positive regulation of developmental process,regulation of phosphorus metabolic process, positive regulation of protein metabolic process, regulation of cell motion,positive regulation of cell motion, regulation of release of sequestered calcium ion into cytosol, histamine transport,response to protein stimulus, regulation of calcium ion transport, regulation of nervous system development,regulation of glial cell proliferation, positive regulation of glial cell proliferation, regulation of cell development,regulation of Fc receptor mediated stimulatory signaling pathway, positive regulation of Fc receptor mediated stimulatory signaling pathway, regulation of stress-activated protein kinase signaling pathway, positive regulation of stress-activated protein kinase signaling pathway, regulation of oligodendrocyte progenitor proliferation, positive regulation of oligodendrocyte progenitor proliferation, regulation of cellular response to stress,

Cell membrane. Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus. Membrane ; Lipid-anchor . Accumulates in the nucleus by inhibition of CRM1-mediated nuclear export. Nuclear accumulation is increased by inhibition of its kinase activity. The trafficking from the Golgi apparatus to the plasma membrane occurs in a kinase domain-dependent but kinase activity independent manner and is mediated by exocytic vesicular transport. Detected on plasma membrane lipid rafts.

Detected in monocytes (at protein level). Detected in placenta, and in fetal brain, lung, liver and kidney. Widely expressed in a variety of organs, tissues, and cell types such as epidermoid, hematopoietic, and neuronal cells. Expressed in primary neuroblastoma tumors.