GRIA1

Glutamate receptor 1 ;
GluR-1 ;
AMPA-selective glutamate receptor 1 ;
GluR-A ;
GluR-K1 ;
Glutamate receptor ionotropic,AMPA 1 ;
GluA1 ;

function:Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change , leading to the opening of the cation channel , and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state , characterized by the presence of bound agonist. ,miscellaneous:The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate. ,PTM:Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-603 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast , Cys-829 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis. ,similarity:Belongs to the glutamate-gated ion channel (TC 1.A.10) family. ,subcellular location:Interaction with CACNG2 promotes cell surface expression. ,subunit:Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. Interacts with DLG1 via its C-terminus. Interacts with CACNG2 , HIP1 and RASGRF2. ,tissue specificity:Widely expressed in brain. ,

ion transport , endocytosis , receptor-mediated endocytosis , cell-cell signaling , synaptic transmission , behavior , learning or memory , memory , long-term memory , membrane invagination , membrane organization , vesicle-mediated transport ,transmission of nerve impulse , receptor internalization , receptor metabolic process , neurological system process ,cognition ,

Cell membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Cell junction , synapse , postsynaptic cell membrane ; Multi-pass membrane protein . Cell junction , synapse , postsynaptic density membrane ; Multi-pass membrane protein . Cell projection , dendrite . Cell projection , dendritic spine . Early endosome membrane ; Multi-pass membrane protein . Recycling endosome membrane ; Multi-pass membrane protein . Cell junction , synapse , presynapse . Cell junction , synapse . Interaction with CACNG2 , CNIH2 and CNIH3 promotes cell surface expression. Colocalizes with PDLIM4 in early endosomes. Displays a somatodendritic localization and is excluded from axons in neurons (By similarity) . Localized to cone photoreceptor pedicles (By similarity) . .