KIF11

Kinesin-like protein KIF11 ;
Kinesin-like protein 1 ;
Kinesin-like spindle protein HKSP ;
Kinesin-related motor protein Eg5 ;
Thyroid receptor-interacting protein 5 ;
TR-interacting protein 5 ;
TRIP-5 ;

function:Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays.,PTM:Phosphorylated exclusively on serine during S phase, but on both serine and Thr-926 during mitosis, so controlling the association of KIF11 with the spindle apparatus (probably during early prophase). Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the kinesin-like protein family. BimC subfamily.,similarity:Contains 1 kinesin-motor domain.,subunit:Interacts with the thyroid hormone receptor in the presence of thyroid hormone. Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5.,

M phase of mitotic cell cycle, microtubule cytoskeleton organization, mitotic cell cycle, M phase, nuclear division,cytoskeleton organization, microtubule-based process, microtubule-based movement, cell cycle, spindle organization,mitotic spindle organization, mitosis, centrosome cycle, mitotic centrosome separation, cell cycle process, cell cycle phase, microtubule organizing center organization, organelle fission, centrosome organization, centrosome separation, spindle pole body organization, cell division,

Cytoplasm . Cytoplasm, cytoskeleton, spindle pole .