NFKBIE

NF-kappa-B inhibitor epsilon ;
NF-kappa-BIE ;
I-kappa-B-epsilon ;
IkB-E ;
IkB-epsilon ;
IkappaBepsilon ;

function:Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes.,PTM:Serine phosphorylated; followed by proteasome-dependent degradation.,similarity:Belongs to the NF-kappa-B inhibitor family.,similarity:Contains 6 ANK repeats.,subunit:Interacts with RELA, REL, NFKB1 nuclear factor NF-kappa-B p50 subunit and NFKB2 nuclear factor NF-kappa-B p52 subunit.,tissue specificity:Highly expressed in spleen, testis and lung, followed by kidney, pancreas, heart, placenta and brain. Also expressed in granulocytes and macrophages.,

amino acid transport, protein localization, neutral amino acid transport, amine transport, organic acid transport, serine transport, regulation of intracellular transport, negative regulation of intracellular transport, maintenance of protein location in cell, regulation of protein localization, regulation of intracellular protein transport, regulation of protein import into nucleus, negative regulation of protein import into nucleus, D-amino acid transport, D-serine transport,regulation of transcription factor import into nucleus, negative regulation of transcription factor import into nucleus,cytoplasmic sequestering of transcription factor, maintenance of protein location, regulation of nucleocytoplasmic transport, negative regulation of nucleocytoplasmic transport, carboxylic acid transport, negative regulation of transport, cytoplasmic sequestering of protein, regulation of protein transport, negative regulation of protein transport, maintenance of location, maintenance of location in cell, regulation of cellular localization, regulation of establishment of protein localization,

Cytoplasm .

Highly expressed in spleen, testis and lung, followed by kidney, pancreas, heart, placenta and brain. Also expressed in granulocytes and macrophages.