NFKBIB

NF-kappa-B inhibitor beta ;
NF-kappa-BIB ;
I-kappa-B-beta ;
IkB-B ;
IkB-beta ;
IkappaBbeta ;
Thyroid receptor-interacting protein 9 ;
TR-interacting protein 9 ;
TRIP-9 ;

function:Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further IKBA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.,PTM:Phosphorylated; followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents phosphorylation.,similarity:Belongs to the NF-kappa-B inhibitor family.,similarity:Contains 6 ANK repeats.,subunit:Interacts with THRB (via ligand-binding domain). Interacts with RELA and REL. Interacts with COMMD1 and inhibitor kappa B-interacting Ras-like NKIRAS1 and NKIRAS2.,tissue specificity:Expressed in all tissues examined.,

transcription, intracellular signaling cascade, protein kinase cascade, I-kappaB kinase/NF-kappaB cascade, cytoplasmic sequestering of NF-kappaB, protein localization, regulation of intracellular transport, negative regulation of intracellular transport, maintenance of protein location in cell, regulation of protein localization, regulation of intracellular protein transport, regulation of protein import into nucleus, negative regulation of protein import into nucleus, regulation of NF-kappaB import into nucleus, negative regulation of NF-kappaB import into nucleus, regulation of transcription factor import into nucleus, negative regulation of transcription factor import into nucleus, cytoplasmic sequestering of transcription factor, maintenance of protein location, regulation of nucleocytoplasmic transport,negative regulation of nucleocytoplasmic transport, negative regulation of transport, cytoplasmic sequestering of protein, regulation of protein transport, negative regulation of protein transport, maintenance of location,maintenance of location in cell, regulation of cellular localization, regulation of establishment of protein localization,

Cytoplasm . Nucleus .

Expressed in all tissues examined.