ILK

Integrin-linked protein kinase ;
59 kDa serine/threonine-protein kinase ;
ILK-1 ;
ILK-2 ;
p59ILK ;

catalytic activity:ATP + a protein = ADP + a phosphoprotein.,domain:A PH-like domain is involved in phosphatidylinositol phosphate binding.,enzyme regulation:Stimulated rapidly but transiently by both cell fibronectin interactions, as well as by insulin, in a PI3-K-dependent manner, likely via the binding of PtdIns(3,4,5)P3 with a PH-like domain of ILK.,function:Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.,PTM:Autophosphorylated on serine residues.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,similarity:Contains 5 ANK repeats.,subunit:Interacts with cytoplasmic domain of beta 1 subunit of integrin. Could also interacts with beta 2, beta 3 and/or beta 5 subunit of integrin. Interacts (via ANK repeats) with LIMS1 and LIMS2. Interacts with parvins and probably TGFB1I1.,tissue specificity:Highly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed in placenta, lung and liver.,

cell morphogenesis, cell morphogenesis involved in differentiation, regulation of action potential, regulation of cell growth, urogenital system development, metanephros development, ureteric bud development, branching involved in ureteric bud morphogenesis, morphogenesis of a branching structure, kidney development, regulation of cell-matrix adhesion, positive regulation of cell-matrix adhesion, morphogenesis of an epithelium, protein complex assembly,protein amino acid phosphorylation, negative regulation of protein kinase activity, phosphorus metabolic process,phosphate metabolic process, cellular ion homeostasis, cell cycle, cell cycle arrest, cell adhesion, cell-matrix adhesion,establishment or maintenance of cell polarity, cell surface receptor linked signal transduction, integrin-mediated signaling pathway, ensheathment of neurons, aging, cell aging, cell proliferation, positive regulation of cell proliferation, negative regulation of cell proliferation, regulation of cell size, axon ensheathment, positive regulation of signal transduction, regulation of protein kinase cascade, positive regulation of cell communication, negative regulation of muscle cell apoptosis, regulation of muscle cell apoptosis, regulation of striated muscle cell apoptosis,negative regulation of striated muscle cell apoptosis, regulation of cardiac muscle cell apoptosis, negative regulation of cardiac muscle cell apoptosis, positive regulation of cell development, positive regulation of protein kinase cascade,regulation of cell morphogenesis involved in differentiation, regulation of cell-substrate adhesion, positive regulation of cell-substrate adhesion, cellular component assembly involved in morphogenesis, regulation of cell death,regulation of neuron projection development, regulation of smooth muscle cell migration, negative regulation of smooth muscle cell migration, regulation of striated muscle tissue development, phosphorylation, peptidyl-serine phosphorylation, peptidyl-serine modification, regulation of phosphate metabolic process, transmission of nerve impulse, regulation of action potential in neuron, cellular homeostasis, cell cycle process, regulation of cell morphogenesis, biological adhesion, cell projection organization, regulation of cell adhesion, neuron differentiation,extracellular matrix organization, positive regulation of cell growth, regulation of cell migration, positive regulation of cell migration, negative regulation of cell migration, regulation of axon extension, neuron projection development,regulation of cell projection organization, positive regulation of cell projection organization, cell-substrate adhesion,myelin assembly, regulation of cellular component size, regulation of actin cytoskeleton organization, regulation of actin filament-based process, cellular component morphogenesis, cell part morphogenesis, regulation of organelle organization, negative regulation of kinase activity, positive regulation of kinase activity, substrate adhesion-dependent cell spreading, establishment or maintenance of apical/basal cell polarity, tube morphogenesis, tube development, regulation of growth, regulation of locomotion, negative regulation of locomotion, positive regulation of locomotion, regulation of cell proliferation, regulation of phosphorylation, regulation of membrane potential,myelination, homeostatic process, regulation of apoptosis, extracellular structure organization, negative regulation of apoptosis, regulation of programmed cell death, negative regulation of programmed cell death, positive regulation of catalytic activity, negative regulation of catalytic activity, fibril organization, regulation of MAP kinase activity, positive regulation of MAP kinase activity, regulation of MAPKKK cascade, positive regulation of MAPKKK cascade, regulation of neuron apoptosis, negative regulation of neuron apoptosis, regulation of kinase activity, macromolecular complex subunit organization, negative regulation of molecular function, positive regulation of molecular function,establishment or maintenance of epithelial cell apical/basal polarity, positive regulation of cell differentiation,regulation of myoblast differentiation, positive regulation of myoblast differentiation, regulation of neuron differentiation, positive regulation of axon extension, positive regulation of cell adhesion, positive regulation of cell size, regulation of protein kinase activity, positive regulation of protein kinase activity, positive regulation of growth,regulation of muscle development, regulation of developmental growth, positive regulation of developmental growth,regulation of skeletal muscle tissue development, regulation of smooth muscle cell proliferation, negative regulation of smooth muscle cell proliferation, neuron development, tissue morphogenesis, regulation of skeletal muscle fiber development, branching morphogenesis of a tube, neuron projection morphogenesis, regulation of dendrite morphogenesis, cell projection morphogenesis, chemical homeostasis, regulation of neurogenesis, positive regulation of neurogenesis, regulation of axonogenesis, positive regulation of axonogenesis, regulation of dendrite development, positive regulation of dendrite morphogenesis, ion homeostasis, neurological system process, positive regulation of developmental process, positive regulation of cellular component organization, regulation of muscle cell differentiation, positive regulation of muscle cell differentiation, regulation of striated muscle cell differentiation,regulation of phosphorus metabolic process, protein oligomerization, regulation of cell motion, negative regulation of cell motion, positive regulation of cell motion, protein heterooligomerization, regulation of transferase activity, positive regulation of transferase activity, negative regulation of transferase activity, regulation of cytoskeleton organization,regulation of protein kinase B signaling cascade, positive regulation of protein kinase B signaling cascade, regulation of nervous system development, cellular chemical homeostasis, regulation of cell development, epithelium development, negative regulation of cell death, epithelial tube morphogenesis, ureteric bud morphogenesis,macromolecular complex assembly, protein complex biogenesis,

Cell junction, focal adhesion . Cell membrane; Peripheral membrane protein; Cytoplasmic side . Cell projection, lamellipodium . Cytoplasm, myofibril, sarcomere .

Highly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed in placenta, lung and liver.