DAB1

DAB1 ;
Disabled homolog 1

domain:The PID domain specifically binds to the Asn-Pro-Xaa-Tyr (P) motif found in many tyrosine-phosphorylated proteins. ,function:Adapter molecule functioning in neural development. May regulate SIAH1 activity. ,PTM:Phosphorylated on Tyr-198 and Tyr-220 upon reelin induction in embryonic neurons (By similarity) . Also phosphorylated on Ser-524 independently of reelin signaling. ,similarity:Contains 1 PID domain. ,subunit:Associates with the SH2 domains of SRC , FYN and ABL. Interacts with DAB2IP and SIAH1 (By similarity) . Interacts with LRP1. ,

neuron migration , cell motion , cell adhesion , negative regulation of cell adhesion , intracellular signaling cascade , small GTPase mediated signal transduction , cell-cell adhesion , cell migration , regulation of phosphate metabolic process , cell migration in hindbrain , telencephalon development , pallium development , cerebellum development , hindbrain morphogenesis , hindbrain structural organization , cerebellum morphogenesis , cerebellum structural organization ,cerebral cortex cell migration , cerebral cortex radially oriented cell migration , cerebral cortex radial glia guided migration , neuronal-glial interaction involved in cerebral cortex radial glia guided migration , cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration , forebrain cell migration , hindbrain radial glia guided cell migration , radial glia guided migration of Purkinje cell , cerebral cortex development ,telencephalon cell migration , metencephalon development , biological adhesion , regulation of cell adhesion , forebrain development , hindbrain development , positive regulation of kinase activity , regulation of phosphorylation , positive regulation of catalytic activity , regulation of kinase activity , positive regulation of molecular function , regulation of protein kinase activity , positive regulation of protein kinase activity , anatomical structure arrangement , cell motility ,regulation of phosphorus metabolic process , regulation of transferase activity , positive regulation of transferase activity , localization of cell ,