Total IL-3Rβ Cell-Based Colorimetric ELISA Kit
-KA4136C
主要信息
Reactivity
Human, Mouse, Rat
Applications
ELISA
Conjugate/Modification
Unmodified
详细信息
储存
2-8°C/6 months
修饰
Unmodified
检测方法
Colorimetric
相关产品
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ELISA Kits
Total IL-3Rβ Cell-Based Colorimetric ELISA Kit
KA4136C
预览→
ELISA Kits
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抗原&靶点信息
基因名称:
CSF2RB
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别名:
Cytokine receptor common subunit beta ;
CDw131 ;
GM-CSF/IL-3/IL-5 receptor common beta subunit ;
CD antigen CD131 ;
CDw131 ;
GM-CSF/IL-3/IL-5 receptor common beta subunit ;
CD antigen CD131 ;
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背景:
disease:Defects in CSF2RB are a cause of congenital pulmonary alveolar proteinosis (PAP) [MIM:265120]. PAP is an autosomal recessive fatal respiratory disease.,domain:The box 1 motif is required for JAK interaction and/or activation.,domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.,function:High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor.,similarity:Belongs to the type I cytokine receptor family. Type 4 subfamily.,similarity:Contains 2 fibronectin type-III domains.,subunit:Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors.,
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功能:
respiratory gaseous exchange, cytokine-mediated signaling pathway,
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细胞定位:
Membrane; Single-pass type I membrane protein.
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信号通路
Cellular Processes >> Cell growth and death >> Apoptosis
Human Diseases >> Cancer: overview >> Pathways in cancer
Environmental Information Processing >> Signal transduction >> JAK-STAT signaling pathway
Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction
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