Cortactin (Phospho Tyr466) Cell-Based Colorimetric ELISA Kit
-KA1068C
主要信息
Reactivity
Human, Mouse, Rat
Applications
ELISA
Conjugate/Modification
Phospho
详细信息
储存
2-8°C/6 months,Ship by ice bag
修饰
Phospho
检测方法
Colorimetric
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抗原&靶点信息
基因名称:
CTTN
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别名:
Src substrate cortactin ;
Amplaxin ;
Oncogene EMS1 ;
Amplaxin ;
Oncogene EMS1 ;
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背景:
function:May contribute to the organization of cell structure. The SH3 motif may function as a binding region to cytoskeleton. Tyrosine phosphorylation in transformed cells may contribute to cellular growth regulation and transformation. ,online information:Cortactin entry ,similarity:Contains 1 SH3 domain. ,similarity:Contains 7 cortactin repeats. ,subcellular location:Associated with membrane ruffles and lamellipodia. ,subunit:Interacts with SHANK2 and SHANK3 via its SH2 domain. Also interacts with FGD1 (By similarity) . Interacts with PLXDC2. ,
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细胞定位:
Cytoplasm , cytoskeleton . Cell projection , lamellipodium . Cell projection , ruffle. Cell projection , dendrite . Cell projection . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection , podosome . Cell junction . Cell junction , focal adhesion . Membrane , clathrin-coated pit . Cell projection , dendritic spine . Cytoplasm , cell cortex . Colocalizes transiently with PTK2/FAK1 at focal adhesions (By similarity) . Associated with membrane ruffles and lamellipodia. In the presence of CTTNBP2NL , colocalizes with stress fibers (By similarity) . In the presence of CTTNBP2 , localizes at the cell cortex (By similarity) . In response to neuronal activation by glutamate , redistributes from dendritic spines to the dendritic shaft (By similarity) . Colocalizes with DNM2 at the basis of filopodia in hippocampus neuron growth zones (By similarity) . .
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