IGFBP3

Insulin-like growth factor-binding protein 3 ;
IBP-3 ;
IGF-binding protein 3 ;
IGFBP-3 ;

developmental stage:IGFBP3 levels are higher during extrauterine life and peak during puberty.,domain:The thyroglobulin type-1 domain mediates interaction with HN.,function:IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.,induction:IGFBP3 levels increase in the presence of IGF1, insulin and other growth-stimulating factors such as growth hormone, epidermal growth factor, and phorbol esters.,online information:The Singapore human mutation and polymorphism database,similarity:Contains 1 IGFBP N-terminal domain.,similarity:Contains 1 thyroglobulin type-1 domain.,subunit:Interacts with XLKD1 (By similarity). Binds IGF2 more than IGF1. Forms a ternary complex of about 140 to 150 kDa with IGF1 or IGF2 and a 85 kDa glycoprotein (ALS). Interacts with HN.,tissue specificity:Expressed by most tissues.,

skeletal system development, ossification, regulation of cell growth, osteoblast differentiation, regulation of protein amino acid phosphorylation, negative regulation of protein amino acid phosphorylation, protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, negative regulation of cell proliferation, negative regulation of signal transduction, negative regulation of phosphorus metabolic process,negative regulation of macromolecule metabolic process, negative regulation of cell communication, regulation of cell death, positive regulation of cell death, regulation of smooth muscle cell migration, negative regulation of smooth muscle cell migration, regulation of striated muscle tissue development, phosphorylation, regulation of phosphate metabolic process, regulation of cell migration, negative regulation of cell migration, regulation of protein modification process, negative regulation of protein modification process, regulation of cellular protein metabolic process, negative regulation of cellular protein metabolic process, regulation of growth, regulation of locomotion, negative regulation of locomotion, regulation of cell proliferation, regulation of phosphorylation, negative regulation of phosphorylation,regulation of apoptosis, positive regulation of apoptosis, regulation of programmed cell death, positive regulation of programmed cell death, positive regulation of cell differentiation, regulation of myoblast differentiation, positive regulation of myoblast differentiation, negative regulation of phosphate metabolic process, regulation of muscle development, regulation of skeletal muscle tissue development, regulation of smooth muscle cell proliferation,negative regulation of smooth muscle cell proliferation, regulation of skeletal muscle fiber development, positive regulation of developmental process, regulation of muscle cell differentiation, positive regulation of muscle cell differentiation, regulation of striated muscle cell differentiation, regulation of phosphorus metabolic process, negative regulation of protein metabolic process, regulation of cell motion, negative regulation of cell motion, regulation of cell development, bone development,

Secreted .

Expressed by most tissues. Present in plasma.