HCLS1

Hematopoietic lineage cell-specific protein ;
Hematopoietic cell-specific LYN substrate 1 ;
LckBP1 ;
p75 ;

developmental stage:Expressed in early stage of myeloid and erythroid differentiation.,function:Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.,PTM:Phosphorylated by LYN; rapidly after cross-linking of surface IgM on B-cells.,similarity:Contains 1 SH3 domain.,similarity:Contains 4 cortactin repeats.,subunit:Associates with the SH2 and SH3 domains of LCK. Binding to he LCK SH3 domain occurs constitutively, while binding to the LCK SH2 domain occurs only upon TCR stimulation. A similar binding pattern was observed with LYN, but not with FYN in which the FYN SH2 region associates upon TCR stimulation but the FYN SH3 region does not associate regardless of TCR stimulation. Directly associates with HAX1, through binding to its C-terminal region. Interacts with HS1BP3.,tissue specificity:Expressed only in tissues and cells of hematopoietic origin.,

regulation of protein amino acid phosphorylation, positive regulation of protein amino acid phosphorylation, immune system development, regulation of transcription, DNA-dependent, intracellular signaling cascade, positive regulation of cell proliferation, response to endogenous stimulus, response to hormone stimulus, positive regulation of signal transduction, response to organic substance, positive regulation of phosphorus metabolic process, positive regulation of macromolecule metabolic process, regulation of protein kinase cascade, positive regulation of cell communication,positive regulation of protein kinase cascade, regulation of phosphate metabolic process, hemopoiesis, myeloid cell differentiation, erythrocyte differentiation, regulation of protein modification process, positive regulation of protein modification process, regulation of cellular protein metabolic process, positive regulation of cellular protein metabolic process, erythrocyte homeostasis, regulation of cell proliferation, regulation of phosphorylation, positive regulation of phosphorylation, regulation of tyrosine phosphorylation of STAT protein, positive regulation of tyrosine phosphorylation of STAT protein, homeostatic process, regulation of transcription, positive regulation of phosphate metabolic process, regulation of JAK-STAT cascade, positive regulation of JAK-STAT cascade, hemopoietic or lymphoid organ development, homeostasis of number of cells, regulation of peptidyl-tyrosine phosphorylation, positive regulation of peptidyl-tyrosine phosphorylation, regulation of phosphorus metabolic process, positive regulation of protein metabolic process, regulation of RNA metabolic process,

Membrane ; Peripheral membrane protein . Cytoplasm . Mitochondrion .

Expressed only in tissues and cells of hematopoietic origin.