HDAC2

Histone deacetylase 2 ;
HD2 ;

catalytic activity:Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.,function:Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1.,function:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.,sequence caution:Intron retention.,similarity:Belongs to the histone deacetylase family. Type 1 subfamily.,subunit:Interacts with the non-histone region of H2AFY (By similarity). Part of the core histone deacetylase (HDAC) complex composed of HDAC1, HDAC2, RBBP4 and RBBP7. The core complex associates with MTA2, MBD3, MTA1L1, CHD3 and CHD4 to form the nucleosome remodeling and histone deacetylation (NuRD) complex, or with SIN3, SAP18 and SAP30 to form the SIN3 HDAC complex. Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, AOF2/LSD1, RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Part of a complex containing the core histones H2A, H2B, H3 and H4, DEK and unphosphorylated DAXX. Part of a complex containing ATR and CHD4. Forms a heterologous complex at least with YY1. Interacts with ATR, DNMT1, MINT, HDAC7, HDAC10, HCFC1, NRIP1, MJD2A/JHDM3A, PRDM6, SAP30, SETDB1 and SUV39H1. Interacts with the non-histone region of H2AFY. Interacts with PELP1. Component of a mSin3A corepressor complex that contains SIN3A, SAP130, SUDS3/SAP45, ARID4B/SAP180, HDAC1 and HDAC2. Interacts with CBFA2T3. Interacts with SAP30L.,tissue specificity:Widely expressed; lower levels in brain and lung.,

negative regulation of transcription from RNA polymerase II promoter, chromatin organization, chromatin remodeling,chromatin silencing, maintenance of chromatin silencing, transcription, regulation of transcription, DNA-dependent,regulation of transcription from RNA polymerase II promoter, protein amino acid deacetylation, positive regulation of cell proliferation, response to temperature stimulus, response to heat, response to abiotic stimulus, negative regulation of biosynthetic process, positive regulation of biosynthetic process, response to organic substance,regulation of specific transcription from RNA polymerase II promoter, positive regulation of specific transcription from RNA polymerase II promoter, negative regulation of specific transcription from RNA polymerase II promoter, positive regulation of macromolecule biosynthetic process, negative regulation of macromolecule biosynthetic process, positive regulation of macromolecule metabolic process, negative regulation of macromolecule metabolic process, positive regulation of gene expression, negative regulation of gene expression, regulation of collagen metabolic process,positive regulation of collagen metabolic process, regulation of receptor biosynthetic process, positive regulation of receptor biosynthetic process, response to organic cyclic substance, response to tropane, gene silencing, negative regulation of transcription, chromatin modification, covalent chromatin modification, histone modification, histone deacetylation, regulation of proteolysis, negative regulation of cellular biosynthetic process, positive regulation of cellular biosynthetic process, regulation of cellular protein metabolic process, positive regulation of cellular protein metabolic process, negative regulation of gene-specific transcription, regulation of gene-specific transcription,regulation of collagen biosynthetic process, positive regulation of collagen biosynthetic process, cellular response to stress, cellular response to heat, regulation of gene expression, epigenetic, regulation of cell proliferation, response to cocaine, response to drug, positive regulation of gene-specific transcription, response to alkaloid, negative regulation of DNA binding, negative regulation of transcription factor activity, negative regulation of molecular function,regulation of multicellular organismal metabolic process, positive regulation of multicellular organismal metabolic process, regulation of MHC class II biosynthetic process, negative regulation of MHC class II biosynthetic process,regulation of transcription, negative regulation of cell cycle, negative regulation of gene expression, epigenetic,positive regulation of proteolysis, negative regulation of transcription, DNA-dependent, positive regulation of transcription, DNA-dependent, negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of transcription, positive regulation of transcription from RNA polymerase II promoter, regulation of transcription factor activity, regulation of binding, negative regulation of binding, regulation of DNA binding, negative regulation of nitrogen compound metabolic process, positive regulation of nitrogen compound metabolic process,positive regulation of multicellular organismal process, positive regulation of protein metabolic process, regulation of RNA metabolic process, negative regulation of RNA metabolic process, positive regulation of RNA metabolic process,chromosome organization, regulation of cell cycle,

Nucleus . Cytoplasm .

Widely expressed; lower levels in brain and lung.