GSK3B

Glycogen synthase kinase-3 beta ;
GSK-3 beta ;
Serine/threonine-protein kinase GSK3B ;

catalytic activity:ATP + [tau protein] = ADP + [tau protein] phosphate.,enzyme regulation:Inhibited when phosphorylated by AKT1.,function:Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin.,PTM:Phosphorylated by AKT1 and ILK1.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Monomer (By similarity). Interacts with CABYR, MUC1, NIN and PRUNE.,tissue specificity:Expressed in testis, thymus, prostate and ovary and weakly expressed in lung, brain and kidney.,

re-entry into mitotic cell cycle, polysaccharide metabolic process, glycogen metabolic process, monosaccharide metabolic process, glucose metabolic process, cellular glucan metabolic process, generation of precursor metabolites and energy, energy reserve metabolic process, protein amino acid phosphorylation, protein targeting, protein export from nucleus, phosphorus metabolic process, phosphate metabolic process, intracellular protein transport,nucleocytoplasmic transport, anti-apoptosis, ER overload response, ER-nuclear signaling pathway, cell cycle, cell surface receptor linked signal transduction, intracellular signaling cascade, protein localization, regulation of cell death,protein transport, energy derivation by oxidation of organic compounds, Wnt receptor signaling pathway,phosphorylation, peptidyl-serine phosphorylation, peptidyl-serine modification, hexose metabolic process, cell cycle process, positive regulation of protein complex assembly, regulation of intracellular transport, positive regulation of intracellular transport, regulation of protein localization, regulation of intracellular protein transport, cellular response to stress, cellular protein localization, response to endoplasmic reticulum stress, regulation of apoptosis, negative regulation of apoptosis, regulation of programmed cell death, negative regulation of programmed cell death,regulation of protein complex assembly, glucan metabolic process, regulation of cellular component biogenesis, cellular polysaccharide metabolic process, establishment of protein localization, fat cell differentiation, regulation of nucleocytoplasmic transport, positive regulation of nucleocytoplasmic transport, regulation of protein export from nucleus, positive regulation of protein export from nucleus, intracellular transport, positive regulation of transport,positive regulation of cellular component organization, nuclear export, nuclear transport, positive regulation of protein transport, regulation of protein transport, Wnt receptor signaling pathway through beta-catenin, regulation of cellular localization, negative regulation of cell death, regulation of establishment of protein localization, cellular macromolecule localization,

Cytoplasm . Nucleus . Cell membrane . The phosphorylated form shows localization to cytoplasm and cell membrane (PubMed:20937854). The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane (PubMed:20937854). .

Expressed in testis, thymus, prostate and ovary and weakly expressed in lung, brain and kidney. Colocalizes with EIF2AK2/PKR and TAU in the Alzheimer disease (AD) brain.