GRB10

Growth factor receptor-bound protein 10 ;
GRB10 adapter protein ;
Insulin receptor-binding protein Grb-IR ;

alternative products:Additional isoforms seem to exist,function:Plays a functional role in insulin and IGF-I signaling. May serve to positively link the insulin and IGF-I receptors to an uncharacterized mitogenic signaling pathway. Interacts with the cytoplasmic domain of the autophosphorylated insulin receptor which is then inhibited. The interaction is mediated by the SH2 domain. Also binds activated platelet-derived growth factor receptor and epidermal growth factor receptor.,similarity:Belongs to the GRB7/10/14 family.,similarity:Contains 1 PH domain.,similarity:Contains 1 Ras-associating domain.,similarity:Contains 1 SH2 domain.,subunit:Interacts with GIGYF1/PERQ1 and GIGYF2/TNRC15.,tissue specificity:Highly expressed in skeletal muscle.,

cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway, transmembrane receptor protein tyrosine kinase signaling pathway, cell-cell signaling, insulin receptor signaling pathway, response to endogenous stimulus, response to hormone stimulus, negative regulation of signal transduction, response to organic substance, negative regulation of cell communication, regulation of glucose transport, negative regulation of glucose transport, response to insulin stimulus, cellular response to insulin stimulus, cellular response to hormone stimulus,response to peptide hormone stimulus, regulation of glucose import, negative regulation of glucose import, regulation of insulin receptor signaling pathway, negative regulation of insulin receptor signaling pathway, insulin-like growth factor receptor signaling pathway, negative regulation of response to stimulus, negative regulation of transport,

Cytoplasm . When complexed with NEDD4 and IGF1R, follows IGF1R internalization, remaining associated with early endosomes. Uncouples from IGF1R-containing endosomes before the sorting of the receptor to the lysosomal compartment (By similarity). .

Widely expressed in fetal and adult tissues, including fetal and postnatal liver, lung, kidney, skeletal muscle, heart, spleen, skin and brain.