CEBPB

CCAAT/enhancer-binding protein beta ;
C/EBP beta ;
Liver activator protein ;
Nuclear factor NF-IL6 ;
Transcription factor 5 ;
TCF-5 ;

function:Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses. Specifically binds to an IL-1 response element in the IL-6 gene. NF-IL6 also binds to regulatory regions of several acute-phase and cytokines genes. It probably plays a role in the regulation of acute-phase reaction , inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. ,PTM:Sumoylated by polymeric chains of SUMO2 or SUMO3. ,similarity:Belongs to the bZIP family. ,similarity:Belongs to the bZIP family. C/EBP subfamily. ,similarity:Contains 1 bZIP domain. ,subunit:Binds DNA as a dimer and can form stable heterodimers with C/EBP alpha , delta and gamma. Interacts with TRIM28 and PTGES2. ,tissue specificity:Expressed at low levels in the lung , kidney and spleen. ,

in utero embryonic development , regulation of cytokine production , placenta development , embryonic placenta development , acute inflammatory response , transcription , transcription , DNA-dependent , regulation of transcription , DNA-dependent , regulation of transcription from RNA polymerase II promoter , transcription from RNA polymerase II promoter , anti-apoptosis , induction of apoptosis , defense response , acute-phase response , inflammatory response ,immune response , response to wounding , embryonic development ending in birth or egg hatching , positive regulation of biosynthetic process , positive regulation of macromolecule biosynthetic process , positive regulation of macromolecule metabolic process , positive regulation of gene expression , regulation of cell death , positive regulation of cell death , induction of programmed cell death , neuron differentiation , positive regulation of cellular biosynthetic process , regulation of interleukin-6 production , RNA biosynthetic process , regulation of cytokine biosynthetic process ,regulation of apoptosis , chordate embryonic development , positive regulation of apoptosis , negative regulation of apoptosis , regulation of programmed cell death , positive regulation of programmed cell death , negative regulation of programmed cell death , regulation of interleukin-6 biosynthetic process , fat cell differentiation , regulation of transcription , positive regulation of transcription , DNA-dependent , positive regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , positive regulation of transcription , positive regulation of transcription from RNA polymerase II promoter , embryonic organ development , positive regulation of nitrogen compound metabolic process , regulation of RNA metabolic process , positive regulation of RNA metabolic process , negative regulation of cell death ,

Nucleus . Cytoplasm . Translocates to the nucleus when phosphorylated at Ser-288. In T-cells when sumoylated drawn to pericentric heterochromatin thereby allowing proliferation (By similarity) . .