FYN

Tyrosine-protein kinase Fyn ;
Proto-oncogene Syn ;
Proto-oncogene c-Fyn ;
Src-like kinase ;
SLK ;
p59-Fyn ;

catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,cofactor:Manganese.,enzyme regulation:Inhibited by phosphorylation of Tyr-531 by leukocyte common antigen and activated by dephosphorylation of this site.,function:Implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels, with isoform 2 showing the greater ability to mobilize cytoplasmic calcium in comparison to isoform 1. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Blocks axon outgrowth and attraction induced by NTN1 by phosphorylating its receptor DDC.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SH3 domain.,subcellular location:Present and active in lipid rafts. Present in cell body and along the process of mature and developing oligodendroyctes.,subunit:Associates through its SH3 domain, to the p85 subunit of phosphatidylinositol 3-kinase. Interacts with the FYN-binding protein (FYB). Interacts with phosphorylated TOM1L1. Interacts with CD79A upon activation of the B-cell antigen receptor which increases FYN activity (By similarity). Interacts with PAG1. Interacts (via SH3 domain) with PRMT8. Interacts with SH2D1A and SLAMF1. Interacts (via SH3 domain) with HEV ORF3 protein.,tissue specificity:Isoform 1 is highly expressed in the brain, isoform 2 is expressed in cells of hemopoietic lineages, especially T lymphocytes.,

neuron migration, cell activation, activation of immune response, immune response-activating cell surface receptor signaling pathway, positive regulation of immune system process, immune response-activating signal transduction,immune response-regulating signal transduction, immune response-regulating cell surface receptor signaling pathway,protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, ion transport,cation transport, calcium ion transport, cell motion, cell surface receptor linked signal transduction, intracellular signaling cascade, protein kinase cascade, sensory perception, behavior, learning or memory, learning, feeding behavior, cell proliferation, regulation of cell shape, detection of external stimulus, detection of abiotic stimulus,response to mechanical stimulus, response to abiotic stimulus, response to organic substance, di-, tri-valent inorganic cation transport, phosphorylation, cell migration, peptidyl-tyrosine phosphorylation, peptidyl-tyrosine modification,sensory perception of pain, regulation of cell morphogenesis, metal ion transport, forebrain development,mononuclear cell proliferation, T cell proliferation, T cell activation, leukocyte activation, response to ethanol,lymphocyte activation, lymphocyte proliferation, protein amino acid autophosphorylation, positive regulation of response to stimulus, cell motility, positive regulation of immune response, activated T cell proliferation, antigen receptor-mediated signaling pathway, T cell receptor signaling pathway, neurological system process, cognition,detection of stimulus involved in sensory perception, sensory perception of mechanical stimulus, detection of mechanical stimulus involved in sensory perception of pain, detection of mechanical stimulus involved in sensory perception, detection of mechanical stimulus, detection of stimulus, localization of cell, leukocyte proliferation,

Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. Palmitoylation is crucial for proper trafficking.

Isoform 1 is highly expressed in the brain. Isoform 2 is expressed in cells of hemopoietic lineages, especially T-lymphocytes.