BCL2

Apoptosis regulator Bcl-2

disease:A chromosomal aberration involving BCL2 may be a cause of follicular lymphoma (FL) [MIM:151430]; also known as type II chronic lymphatic leukemia. Translocation t (14;18) (q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions. ,domain:The BH4 motif is required for anti-apoptotic activity and for interaction with RAF-1. ,function:Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) . ,online information:Bcl-2 entry ,PTM:Phosphorylation/dephosphorylation on Ser-70 regulates anti-apoptotic activity. Growth factor-stimulated phosphorylation on Ser-70 by PKC is required for the anti-apoptosis activity and occurs during the G2/M phase of the cell cycle. In the absence of growth factors , BCL2 appears to be phosphorylated by other protein kinases such as ERKs and stress-activated kinases. Dephosphorylated by protein phosphatase 2A (PP2A) . ,PTM:Proteolytically cleaved by caspases during apoptosis. The cleaved protein , lacking the BH4 motif , has pro-apoptotic activity , causes the release of cytochrome c into the cytosol promoting further caspase activity. ,similarity:Belongs to the Bcl-2 family. ,subunit:Forms homodimers , and heterodimers with BAX , BAD , BAK and Bcl-X (L) . Heterodimerization with BAX requires intact BH1 and BH2 motifs , and is necessary for anti-apoptotic activity (By similarity) . Also interacts with APAF1 , RAF-1 , TP53BP2 , BBC3 , BCL2L1 , MRPL41 and BNIPL. Binding to FKBP8 seems to target BCL2 to the mitochondria and probably interferes with the binding of BCL2 to its targets. ,tissue specificity:Expressed in a variety of tissues. ,

G1/S transition of mitotic cell cycle , mitotic cell cycle , response to reactive oxygen species , cell morphogenesis , cell morphogenesis involved in differentiation , response to acid , skeletal system development , ossification , ovarian follicle development , regulation of cell growth , urogenital system development , metanephros development , ureteric bud development , branching involved in ureteric bud morphogenesis , behavioral fear response , response to hypoxia ,morphogenesis of a branching structure , cell activation , leukocyte homeostasis , B cell homeostasis , kidney development , release of cytochrome c from mitochondria , tissue homeostasis , regulation of protein amino acid phosphorylation , positive regulation of protein amino acid phosphorylation , hair follicle development , regulation of cell-matrix adhesion , morphogenesis of an epithelium , behavioral defense response , hemopoietic progenitor cell differentiation , immune effector process , lymphocyte homeostasis , lymphoid progenitor cell differentiation , B cell lineage commitment , T cell lineage commitment , immune system development , leukocyte differentiation , reproductive developmental process , renal system process , protein amino acid phosphorylation , protein amino acid dephosphorylation , melanin metabolic process , phosphorus metabolic process , phosphate metabolic process , oxygen and reactive oxygen species metabolic process , regulation of nitrogen utilization , mitochondrial transport , cellular ion homeostasis , cellular calcium ion homeostasis , cellular metal ion homeostasis , apoptosis , anti-apoptosis , defense response , immune response , humoral immune response , response to oxidative stress , mitochondrion organization ,mitochondrial membrane organization , cytoskeleton organization , actin filament organization , cell-substrate junction assembly , cell cycle , cell adhesion , cell-matrix adhesion , gamete generation , germ cell development , female gamete generation , regulation of mitotic cell cycle , ectoderm development , axonogenesis , sensory organ development , sex differentiation , female pregnancy , aging , cell aging , response to nutrient , behavior , cell death , cell proliferation ,positive regulation of cell proliferation , negative regulation of cell proliferation , regulation of cell size , gonad development , epidermis development , male gonad development , female gonad development , activation of pro-apoptotic gene products , apoptotic mitochondrial changes , response to temperature stimulus , response to radiation ,response to heat , response to UV , response to light stimulus , response to wounding , response to virus , response to abiotic stimulus , response to toxin , response to endogenous stimulus , response to hormone stimulus , post-embryonic development , response to extracellular stimulus , oocyte differentiation , response to organic substance , response to inorganic substance , response to metal ion , response to iron ion , response to aluminum ion , response to ionizing radiation , response to UV-B , response to gamma radiation , regulation of calcium ion transport into cytosol , negative regulation of calcium ion transport into cytosol , regulation of glycoprotein biosynthetic process , positive regulation of phosphorus metabolic process , positive regulation of macromolecule metabolic process , posttranscriptional regulation of gene expression , positive regulation of cell development , regulation of cell-substrate adhesion , regulation of cell death , positive regulation of cell death , regulation of metal ion transport , programmed cell death , mesenchymal cell development , regulation of neuron maturation , positive regulation of neuron maturation , response to organic cyclic substance , response to purine , regulation of smooth muscle cell migration , positive regulation of smooth muscle cell migration , membrane organization , cell growth , vesicle organization , regulation of striated muscle tissue development ,death , phosphorylation , dephosphorylation , cell-cell adhesion , peptidyl-serine phosphorylation , peptidyl-threonine phosphorylation , peptidyl-serine modification , peptidyl-threonine modification , regulation of phosphate metabolic process , cellular homeostasis , secondary metabolic process , sexual reproduction , pons development , cochlear nucleus development , metencephalon development , cell cycle process , cell cycle phase , molting cycle process , hair cycle process , ovulation cycle process , biological adhesion , gland morphogenesis , cellular cation homeostasis , cellular di- , tri-valent inorganic cation homeostasis , actin filament-based process , cell projection organization , actin cytoskeleton organization , hemopoiesis , lymphocyte differentiation , regulation of cell adhesion , neuron differentiation , B cell differentiation , T cell differentiation , regulation of ossification , negative regulation of ossification , negative regulation of cell growth , melanocyte differentiation , regulation of cell migration , positive regulation of cell migration , negative regulation of cell migration , hindbrain development , response to caffeine , hair follicle morphogenesis , regeneration ,neuron projection regeneration , axon regeneration , neuron projection development , regulation of protein modification process , positive regulation of protein modification process , cell-substrate adhesion , regulation of protein stability ,response to nutrient levels , response to corticosteroid stimulus , regulation of cellular protein metabolic process ,positive regulation of cellular protein metabolic process , endoplasmic reticulum calcium ion homeostasis , multicellular organism reproduction , regulation of cellular component size , glomerulus development , regulation of homeostatic process , negative regulation of homeostatic process , regulation of cellular pH reduction , negative regulation of cellular pH reduction , regulation of protein localization , mononuclear cell proliferation , cellular component morphogenesis , cell part morphogenesis , regulation of myeloid cell apoptosis , negative regulation of myeloid cell apoptosis , cellular pigmentation , T cell differentiation in the thymus , regulation of peptidyl-serine phosphorylation , positive regulation of peptidyl-serine phosphorylation , response to vitamin , cellular response to stress , multicellular organismal response to stress , regulation of osteoblast proliferation , negative regulation of osteoblast proliferation , response to cytokine stimulus , cell junction assembly , cell junction organization , response to nicotine , tube morphogenesis , organ growth ,tube development , growth , regulation of growth , regulation of locomotion , negative regulation of locomotion ,regulation of multicellular organism growth , positive regulation of locomotion , positive regulation of multicellular organism growth , B cell proliferation , T cell activation , B cell activation , regulation of cell proliferation , molting cycle ,regulation of phosphorylation , positive regulation of phosphorylation , regulation of membrane potential , pigment metabolic process , response to drug , response to hydrogen peroxide , homeostatic process , fear response , hair cycle ,ovulation cycle , regulation of apoptosis , T cell homeostasis , positive regulation of apoptosis , negative regulation of apoptosis , regulation of programmed cell death , positive regulation of programmed cell death , negative regulation of programmed cell death , positive regulation of catalytic activity , regulation of ion transport , negative regulation of ion transport , response to alkaloid , positive T cell selection , CD4-positive or CD8-positive , alpha-beta T cell lineage commitment , CD8-positive , alpha-beta T cell differentiation , CD8-positive , alpha-beta T cell lineage commitment ,regulation of protein binding , response to peptide hormone stimulus , pigmentation , regulation of protein homodimerization activity , regulation of protein heterodimerization activity , regulation of neuron apoptosis , negative regulation of neuron apoptosis , ear development , response to estrogen stimulus , positive regulation of molecular function , T cell selection , regulation of viral genome replication , development of primary sexual characteristics , cell fate commitment , leukocyte activation , response to ethanol , positive regulation of cell differentiation , regulation of melanocyte differentiation , positive regulation of melanocyte differentiation , regulation of neuron differentiation ,negative regulation of cell cycle , negative regulation of cell size , positive regulation of striated muscle development ,negative regulation of growth , positive regulation of growth , negative regulation of mitotic cell cycle , positive regulation of phosphate metabolic process , development of primary female sexual characteristics , development of primary male sexual characteristics , alpha-beta T cell activation , alpha-beta T cell differentiation , lymphocyte activation , lymphocyte proliferation , female sex differentiation , male sex differentiation , regulation of retinal cell programmed cell death , negative regulation of retinal cell programmed cell death , response to copper ion , regulation of mitochondrial membrane permeability , intracellular transport , focal adhesion formation , pigmentation during development , regulation of pigmentation during development , positive regulation of pigmentation during development , oogenesis , rhythmic process , hemopoietic or lymphoid organ development , spleen development , thymus development , response to steroid hormone stimulus , digestive tract morphogenesis , gut morphogenesis , gut development , developmental growth , oocyte development , reproductive structure development , reproductive process in a multicellular organism , reproductive cellular process , regulation of muscle development , positive regulation of muscle development , regulation of skeletal muscle tissue development , positive regulation of skeletal muscle tissue development , neuron development , cell morphogenesis involved in neuron differentiation , response to axon injury ,tissue morphogenesis , epidermis morphogenesis , gland development , regulation of skeletal muscle fiber development ,positive regulation of skeletal muscle fiber development , pigment granule organization , branching morphogenesis of a tube , mesenchymal cell differentiation , neuron projection morphogenesis , neural nucleus development , cell projection morphogenesis , multicellular organismal homeostasis , homeostasis of number of cells , homeostasis of number of cells within a tissue , chemical homeostasis , regulation of neurogenesis , regulation of viral reproduction , ion homeostasis ,pigment cell differentiation , regulation of pigment cell differentiation , positive regulation of pigment cell differentiation ,negative regulation of transport , positive regulation of developmental process , regulation of binding , regulation of muscle cell differentiation , positive regulation of muscle cell differentiation , regulation of striated muscle cell differentiation , positive regulation of striated muscle cell differentiation , regulation of phosphorus metabolic process ,positive regulation of multicellular organismal process , positive regulation of protein metabolic process , regulation of cell motion , negative regulation of cell motion , positive regulation of cell motion , interphase , interphase of mitotic cell cycle , response to glucocorticoid stimulus , response to mineralocorticoid stimulus , neuron apoptosis , response to corticosterone stimulus , response to folic acid , defense response to virus , regulation of cell cycle , response to protein stimulus , regulation of mitochondrial membrane potential , membrane depolarization , regulation of mitochondrial depolarization , negative regulation of mitochondrial depolarization , regulation of calcium ion transport , negative regulation of calcium ion transport , regulation of nervous system development , metal ion homeostasis , di- , tri-valent inorganic cation homeostasis , calcium ion homeostasis , cation homeostasis , cellular chemical homeostasis , digestive system development , anatomical structure homeostasis , regulation of cell development , bone development ,epithelium development , mesenchyme development , negative regulation of cell death , epithelial tube morphogenesis ,ureteric bud morphogenesis , apoptosis in response to endoplasmic reticulum stress , response to oxygen levels ,leukocyte proliferation ,

Mitochondrion outer membrane ; Single-pass membrane protein . Nucleus membrane ; Single-pass membrane protein . Endoplasmic reticulum membrane ; Single-pass membrane protein . Cytoplasm .