BAD

Bcl2 antagonist of cell death ;
BAD ;
Bcl-2-binding component 6 ;
Bcl-2-like protein 8 ;
Bcl2-L-8 ;
Bcl-XL/Bcl-2-associated death promoter ;

domain:Intact BH3 motif is required by BIK , BID , BAK , BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family. ,function:Promotes cell death. Successfully competes for the binding to Bcl-X (L) , Bcl-2 and Bcl-W , thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X (L) , but not that of Bcl-2 (By similarity) . Appears to act as a link between growth factor receptor signaling and the apoptotic pathways. ,online information:Bcl 2-associated death promoter entry ,PTM:Phosphorylated on one or more of Ser-75 , Ser-99 , Ser-118 and Ser-134 in response to survival stimuli , which blocks its pro-apoptotic activity. Phosphorylation on Ser-99 or Ser-75 promotes heterodimerization with 14-3-3 proteins. This interaction then facilitates the phosphorylation at Ser-118 , a site within the BH3 motif , leading to the release of Bcl-X (L) and the promotion of cell survival. Ser-99 is the major site of AKT/PKB phosphorylation , Ser-118 the major site of protein kinase A (CAPK) phosphorylation. ,similarity:Belongs to the Bcl-2 family. ,subcellular location:Upon phosphorylation , locates to the cytoplasm. ,subunit:Forms heterodimers with the anti-apoptotic proteins , Bcl-X (L) , Bcl-2 and Bcl-W. Also binds protein S100A10 (By similarity) . The Ser-75/Ser-99 phosphorylated form binds 14-3-3 proteins. ,tissue specificity:Expressed in a wide variety of tissues. ,

positive regulation of immune system process , regulation of leukocyte activation , positive regulation of leukocyte activation , monosaccharide metabolic process , glucose metabolic process , glucose catabolic process , apoptosis ,induction of apoptosis , cell death , cell proliferation , induction of apoptosis by extracellular signals , activation of pro-apoptotic gene products , regulation of cell death , positive regulation of cell death , programmed cell death , induction of programmed cell death , carbohydrate catabolic process , death , cytokine-mediated signaling pathway , hexose metabolic process , hexose catabolic process , carbohydrate homeostasis , homeostatic process , glucose homeostasis ,regulation of apoptosis , positive regulation of apoptosis , regulation of programmed cell death , positive regulation of programmed cell death , regulation of caspase activity , cellular carbohydrate catabolic process , regulation of B cell differentiation , positive regulation of B cell differentiation , regulation of T cell differentiation , positive regulation of T cell differentiation , positive regulation of cell differentiation , regulation of lymphocyte differentiation , positive regulation of lymphocyte differentiation , alcohol catabolic process , monosaccharide catabolic process , chemical homeostasis ,regulation of T cell activation , regulation of B cell activation , regulation of cell activation , positive regulation of cell activation , positive regulation of T cell activation , positive regulation of B cell activation , positive regulation of developmental process , regulation of lymphocyte activation , positive regulation of lymphocyte activation , regulation of hydrolase activity , regulation of peptidase activity , regulation of endopeptidase activity ,

Mitochondrion outer membrane. Cytoplasm . Colocalizes with HIF3A in the cytoplasm (By similarity) . Upon phosphorylation , locates to the cytoplasm. .