EPB49

Dematin ;
Erythrocyte membrane protein band 4.9 ;

domain:Consists of a large core fragment, the amino-terminal portion, and a small headpiece, the C-terminal portion. The headpiece can bind but cannot bundle actin filaments.,domain:Contains at least two actin-binding sites, one in the headpiece domain and one in the amino-terminal portion.,function:Actin-bundling protein. May function in mitogen-activated protein kinase pathway.,PTM:Actin-bundling activity is abolished upon phosphorylation by cAMP-dependent protein kinase.,PTM:The N-terminus is blocked.,similarity:Belongs to the villin/gelsolin family.,similarity:Contains 1 HP (headpiece) domain.,subunit:Exists in solution as a trimer of two short isoforms and one long isoform linked by disulfide bonds (Probable). Interacts with RASGRF2.,tissue specificity:Heart, brain, lung, skeletal muscle, and kidney.,

cytoskeleton organization, actin filament organization, regulation of actin polymerization or depolymerization, negative regulation of organelle organization, actin filament-based process, actin cytoskeleton organization, regulation of actin filament length, regulation of actin filament polymerization, regulation of actin filament depolymerization, negative regulation of actin filament depolymerization, negative regulation of actin filament polymerization, negative regulation of protein complex assembly, regulation of protein polymerization, negative regulation of protein polymerization,regulation of cellular component size, regulation of actin cytoskeleton organization, regulation of actin filament-based process, regulation of organelle organization, negative regulation of protein complex disassembly, regulation of protein complex disassembly, regulation of protein complex assembly, regulation of cellular component biogenesis,actin filament bundle formation, negative regulation of cellular component organization, regulation of cytoskeleton organization, negative regulation of cytoskeleton organization, actin filament capping,

Cytoplasm. Cytoplasm, cytosol. Cytoplasm, perinuclear region . Cytoplasm, cytoskeleton. Cell membrane. Membrane . Endomembrane system. Cell projection . Localized at the spectrin-actin junction of erythrocyte plasma membrane. Localized to intracellular membranes and the cytoskeletal network. Localized at intracellular membrane-bounded organelle compartment in platelets that likely represent the dense tubular network membrane. Detected at the cell membrane and at the parasitophorous vacuole in malaria-infected erythrocytes at late stages of plasmodium berghei or falciparum development.

Expressed in platelets (at protein level). Expressed in heart, brain, lung, skeletal muscle, and kidney.