TP53BP1

Tumor suppressor p53-binding protein 1

TP53BP1 ;
Tumor suppressor p53-binding protein 1 ;
53BP1 ;
p53-binding protein 1 ;
p53BP1

This gene encodes a protein that functions in the DNA double-strand break repair pathway choice , promoting non-homologous end joining (NHEJ) pathways , and limiting homologous recombination. This protein plays multiple roles in the DNA damage response , including promoting checkpoint signaling following DNA damage , acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin , and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V (D) J recombination , class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq , Aug 2017]

Function:May have a role in checkpoint signaling during mitosis (By similarity) . Enhances TP53-mediated transcriptional activation. Plays a role in the response to DNA damage. ,PTM:Asymmetrically dimethylated on Arg residues by PRMT1. Methylation is required for DNA binding. ,PTM:Phosphorylated at basal level in the absence of DNA damage. Hyper-phosphorylated in an ATM-dependent manner in response to DNA damage induced by ionizing radiation. Hyper-phosphorylated in an ATR-dependent manner in response to DNA damage induced by UV irradiation. ,similarity:Contains 2 BRCT domains. ,subcellular location:Associated with kinetochores. Both nuclear and cytoplasmic in some cells. Recruited to sites of DNA damage , such as double stand breaks. Methylation of histone H4 at 'Lys-20' is required for efficient localization to double strand breaks. ,subunit:Interacts with IFI202A (By similarity) . Binds to the central domain of TP53/p53. May form homo-oligomers. Interacts with DCLRE1C. Interacts with histone H2AFX and this requires phosphorylation of H2AFX on 'Ser-139'. Interacts with histone H4 that has been dimethylated at 'Lys-20'. Has low affinity for histone H4 containing monomethylated 'Lys-20'. Does not bind histone H4 containing unmethylated or trimethylated 'Lys-20'. Has low affinity for histone H3 that has been dimethylated on 'Lys-79'. Has very low affinity for histone H3 that has been monomethylated on 'Lys-79' (in vitro) . Does not bind unmethylated histone H3. ,

Nucleus

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