YWHAZ

14-3-3 protein zeta/delta ;
Protein kinase C inhibitor protein 1 ;
KCIP-1 ;

caution:Was originally (PubMed:1577711) thought to have phospholipase A2 activity. ,function:Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners , usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. ,PTM:The delta , brain-specific form differs from the zeta form in being phosphorylated (By similarity) . Phosphorylation on Ser-184 by MAPK8; promotes dissociation of BAX and translocation of BAX to mitochondria. Phosphorylation on Ser-58 by PKA; disrupts homodimerization and heterodimerization with YHAE and TP53. This phosphorylation appears to be activated by sphingosine. Phosphorylation on Thr-232; inhibits binding of RAF1. ,similarity:Belongs to the 14-3-3 family. ,subcellular location:Located to stage I to stage IV melanosomes. ,subunit:Homodimer. Heterodimerizes with YWHAE. Homo- and hetero-dimerization is inhibited by phosphorylation on Ser-58. Interacts with FOXO4 , NOXA1 , SSH1 and ARHGEF2. Interacts with PCTK1 and BSPRY (By similarity) . Interacts with WEE1 (C-terminal) (By similarity) . Interacts with MLF1 (phosphorylated form) ; the interaction retains it in the cytoplasm (By similarity) . Interacts with Thr-phosphorylated ITGB2 (By similarity) . Interacts with Pseudomonas aeruginosa exoS (unphosphorylated form) . Interacts with BAX; the interaction occurs in the cytoplasm. Under stress conditions , MAPK8-mediated phosphorylation releases BAX to mitochondria. Interacts with phosphorylated RAF1; the interaction is inhibited when YWHAZ is phosphorylated on Thr-232. Interacts with TP53; the interaction enhances p53 transcriptional acivity. The Ser-58 phosphorylated form inhibits this interaction and p53 transcriptional activity. Interacts with ABL1 (phosphorylated form) ; the interaction retains ABL1 in the cytoplasm. Interacts with AANAT ('Thr-31' phosphorylated form) ; the interaction modulates AANAT enzymatic activity through preventing dephosphorylation and/or proteolysis and stabilizing substrate binding. Subsequently , a second molecule of AANAT ('Ser-205' phosphorylated form) , can bind the other YWHAZ monomer with similar effect. Interacts with AKT1; the interaction phosphorylates YWHAZ and modulates dimerization. ,

cell activation , histamine secretion , immune effector process , cell activation during immune response , myeloid leukocyte activation , myeloid cell activation during immune response , histamine production during acute inflammatory response , leukocyte activation during immune response , histamine secretion during acute inflammatory response ,leukocyte mediated immunity , myeloid leukocyte mediated immunity , mast cell mediated immunity , acute inflammatory response , production of molecular mediator of acute inflammatory response , histamine secretion by mast cell ,generation of a signal involved in cell-cell signaling , protein targeting , protein targeting to mitochondrion ,mitochondrial transport , intracellular protein transport , exocytosis , anti-apoptosis , defense response , inflammatory response , immune response , mitochondrion organization , cell-cell signaling , protein localization , response to wounding , hormone transport , regulation of hormone levels , regulation of cell death , protein transport , amine transport , vesicle-mediated transport , protein import , secretion by cell , protein localization in organelle , cellular protein localization , response to drug , regulation of apoptosis , negative regulation of apoptosis , regulation of programmed cell death , negative regulation of programmed cell death , leukocyte degranulation , mast cell degranulation , regulated secretory pathway , establishment of protein localization , leukocyte activation , mast cell activation , hormone secretion ,secretion , intracellular transport , histamine transport , negative regulation of cell death , protein localization in mitochondrion , cellular macromolecule localization ,

Cytoplasm . Melanosome . Located to stage I to stage IV melanosomes.