14-3-3 θ/τ (Phospho Ser232) Cell-Based Colorimetric ELISA Kit
-KA1002C
主要信息
Reactivity
Human, Mouse, Rat, Chicken(testedbyourcustomer）
Applications
ELISA
Conjugate/Modification
Phospho
详细信息
储存
2-8°C/6 months,Ship by ice bag
修饰
Phospho
检测方法
Colorimetric
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ELISA Kits
14-3-3 θ/τ (Phospho Ser232) Cell-Based Colorimetric ELISA Kit
KA1002C
预览→
抗原&靶点信息
基因名称:
YWHAQ
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别名:
14-3-3 protein theta ;
14-3-3 protein T-cell ;
14-3-3 protein tau ;
Protein HS1 ;
14-3-3 protein T-cell ;
14-3-3 protein tau ;
Protein HS1 ;
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背景:
function:Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners , usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. ,similarity:Belongs to the 14-3-3 family. ,subcellular location:In neurons , axonally transported to the nerve terminals. ,subunit:Homodimer. Interacts with PCTK1 (By similarity) . Interacts with SSH1. Interacts with CDKN1B ('Thr-198' phosphorylated form) ; the interaction translocates CDKN1B to the cytoplasm. ,tissue specificity:Abundantly expressed in brain , heart and pancreas , and at lower levels in kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with controls , with highest levels of expression in individuals with predominant lower motor neuron involvement. ,
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功能:
regulation of transcription , DNA-dependent , protein targeting , intracellular protein transport , intracellular signaling cascade , small GTPase mediated signal transduction , protein localization , negative regulation of biosynthetic process ,negative regulation of macromolecule biosynthetic process , negative regulation of macromolecule metabolic process ,negative regulation of gene expression , protein transport , negative regulation of transcription , negative regulation of cellular biosynthetic process , cellular protein localization , establishment of protein localization , regulation of transcription , negative regulation of transcription , DNA-dependent , negative regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , intracellular transport , negative regulation of nitrogen compound metabolic process , regulation of RNA metabolic process , negative regulation of RNA metabolic process , cellular macromolecule localization ,
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细胞定位:
Cytoplasm. In neurons , axonally transported to the nerve terminals.
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信号通路
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