PLA2G4A

Cytosolic phospholipase A2 ;
cPLA2 ;
Phospholipase A2 group IVA ;
[Includes: Phospholipase A2 ;
Phosphatidylcholine 2-acylhydrolase ;
Lysophospholipase ;
]

catalytic activity:2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate.,catalytic activity:Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.,domain:The N-terminal C2 domain, by its association with lipid membranes, mediates the regulation of CPLA2 by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+).,enzyme regulation:Stimulated by agonists such as ATP, EGF, thrombin and bradykinin as well as by cytosolic Ca(2+).,function:Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.,PTM:Activated by phosphorylation at both Ser-505 and Ser-727.,similarity:Contains 1 C2 domain.,similarity:Contains 1 PLA2c domain.,subcellular location:Translocates to membrane vesicles in a calcium-dependent fashion.,subunit:Interacts with HTATIP.,tissue specificity:Expressed in various tissues such as macrophages, platelets, neutrophils, fibroblasts and lung endothelium.,

very-long-chain fatty acid metabolic process, response to reactive oxygen species, ovulation from ovarian follicle,luteolysis, placenta development, maternal placenta development, tissue homeostasis, response to molecule of bacterial origin, regulation of acute inflammatory response, positive regulation of acute inflammatory response,reproductive developmental process, cellular amino acid derivative metabolic process, biogenic amine metabolic process, fatty acid metabolic process, phospholipid metabolic process, glycerophospholipid metabolic process, platelet activating factor biosynthetic process, icosanoid metabolic process, response to oxidative stress, gamete generation,female gamete generation, sex differentiation, female pregnancy, aging, response to nutrient, positive regulation of cell proliferation, gonad development, female gonad development, lipid biosynthetic process, phospholipid biosynthetic process, response to temperature stimulus, phospholipid catabolic process, response to heat, response to bacterium,response to abiotic stimulus, response to endogenous stimulus, response to hormone stimulus, positive regulation of biosynthetic process, response to extracellular stimulus, response to organic substance, response to inorganic substance, response to metal ion, response to organic nitrogen, regulation of cellular ketone metabolic process,positive regulation of organelle organization, regulation of cell death, positive regulation of cell death, lipid catabolic process, regulation of lipid metabolic process, regulation of fatty acid metabolic process, arachidonic acid metabolic process, organophosphate metabolic process, sexual reproduction, ovulation cycle process, regulation of ossification,regulation of bone mineralization, positive regulation of bone mineralization, ovulation, positive regulation of cellular biosynthetic process, regulation of vesicle fusion, positive regulation of vesicle fusion, positive regulation of defense response, regulation of prostaglandin biosynthetic process, positive regulation of prostaglandin biosynthetic process,regulation of fever, positive regulation of fever, regulation of heat generation, positive regulation of heat generation,response to nutrient levels, response to corticosteroid stimulus, regulation of response to external stimulus, positive regulation of response to external stimulus, response to lipopolysaccharide, multicellular organism reproduction,regulation of homeostatic process, positive regulation of homeostatic process, regulation of organelle organization,response to vitamin, response to vitamin D, unsaturated fatty acid metabolic process, regulation of cell proliferation,regulation of fatty acid biosynthetic process, ethanolamine and derivative metabolic process, response to hydrogen peroxide, homeostatic process, ovulation cycle, regulation of apoptosis, positive regulation of apoptosis, regulation of programmed cell death, positive regulation of programmed cell death, surfactant homeostasis, cellular lipid catabolic process, glycerolipid biosynthetic process, development of primary sexual characteristics, positive regulation of fatty acid biosynthetic process, positive regulation of ossification, positive regulation of lipid metabolic process, positive regulation of fatty acid metabolic process, platelet activating factor metabolic process, glycerophospholipid biosynthetic process, glycerolipid metabolic process, development of primary female sexual characteristics, female sex differentiation, decidualization, positive regulation of lipid biosynthetic process, regulation of lipid biosynthetic process,rhythmic process, response to steroid hormone stimulus, positive regulation of response to stimulus, reproductive structure development, reproductive process in a multicellular organism, multicellular organismal homeostasis,chemical homeostasis within a tissue, chemical homeostasis, regulation of inflammatory response, positive regulation of inflammatory response, positive regulation of transport, positive regulation of developmental process, positive regulation of cellular component organization, positive regulation of multicellular organismal process, response to glucocorticoid stimulus, response to calcium ion, response to methylmercury, anatomical structure homeostasis,regulation of vesicle-mediated transport, regulation of biomineral formation, positive regulation of biomineral formation,

Cytoplasm . Golgi apparatus membrane . Nucleus envelope. Translocates to intracellular membranes in a calcium-dependent way. .

Expressed in various cells and tissues such as macrophages, neutrophils, fibroblasts and lung endothelium. Expressed in platelets (at protein level) (PubMed:25102815).