CALM1

Calmodulin ;
CaM ;

function:Calmodulin mediates the control of a large number of enzymes and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CEP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis.,miscellaneous:This protein has four functional calcium-binding sites.,PTM:Phosphorylation results in a decreased activity.,PTM:Ubiquitination results in a strongly decreased activity.,similarity:Belongs to the calmodulin family.,similarity:Contains 4 EF-hand domains.,subcellular location:Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules.,subunit:Interacts with MYO1C (By similarity). Interacts with CEP97, CEP110, TTN/titin and SRY.,

cell cycle, cell surface receptor linked signal transduction, G-protein coupled receptor protein signaling pathway,response to inorganic substance, response to metal ion, regulation of calcium ion transport into cytosol, regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum, regulation of metal ion transport, regulation of transmembrane transporter activity, regulation of intracellular transport, regulation of transporter activity, negative regulation of transporter activity, positive regulation of transporter activity, regulation of ion transmembrane transporter activity, negative regulation of ion transmembrane transporter activity, positive regulation of ion transmembrane transporter activity, regulation of cytokinesis, regulation of homeostatic process, regulation of transmembrane transport, regulation of ion transmembrane transport, regulation of ion transport, positive regulation of DNA binding, negative regulation of molecular function, positive regulation of molecular function, positive regulation of transport, negative regulation of transport, regulation of binding, positive regulation of binding, regulation of DNA binding, regulation of release of sequestered calcium ion into cytosol, regulation of cell division, response to calcium ion, regulation of calcium ion transport, regulation of ryanodine-sensitive calcium-release channel activity, negative regulation of ryanodine-sensitive calcium-release channel activity, positive regulation of ryanodine-sensitive calcium-release channel activity, regulation of cellular localization,