ATF5

Cyclic AMP-dependent transcription factor ATF-5 ;
cAMP-dependent transcription factor ATF-5 ;
Activating transcription factor 5 ;
Transcription factor ATFx ;

function:Transcriptional activator which binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters and blocks the differentiation of neuroprogenitor cells into neurons. Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4.,similarity:Belongs to the bZIP family.,similarity:Contains 1 bZIP domain.,subunit:Binds DNA as a dimer. Interacts with PTP4A1/PRL-1 (By similarity). Interacts with CCND3, but not with CCND1 or CCND2.,

transcription, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter,anti-apoptosis, negative regulation of cell development, regulation of cell death, regulation of gliogenesis, negative regulation of gliogenesis, regulation of apoptosis, negative regulation of apoptosis, regulation of programmed cell death, negative regulation of programmed cell death, regulation of transcription, negative regulation of cell differentiation, regulation of glial cell differentiation, negative regulation of glial cell differentiation, regulation of astrocyte differentiation, negative regulation of astrocyte differentiation, regulation of neurogenesis, negative regulation of neurogenesis, regulation of RNA metabolic process, regulation of nervous system development,regulation of cell development, negative regulation of cell death,

Cytoplasm . Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Actively transported to the centrosome and accumulated in the pericentriolar material (PCM) during G1 to M phase via a microtubule-dependent mechanism. During late telophase and cytokinesis, translocates from the centrosome to the midbody. .

Widely expressed with higher expression levels in liver.