CD183 (PTF0058) Mouse mAb
-YF0059
主要信息
Target
CD183
Host Species
Mouse
Reactivity
Human
Applications
FC, IF
Conjugate/Modification
Unmodified
详细信息
推荐稀释比
IF 1:200-1:1000; FC:1 µg per million cells in 100 µl volume. For optimal results, the reagent should be titrated according to each specific application
组成
PBS, pH 7.4
特异性
Endogenous
纯化工艺
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
储存
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
浓度
0.5mg/ml
修饰
Unmodified
克隆性
Monoclonal
克隆号
PTF0058
同种型
Mouse IgG1/Kappa
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抗原&靶点信息
免疫原:
The specific immunogen used to produce this antibody is proprietary information.
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特异性:
Endogenous
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基因名称:
CXCR3 GPR9
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蛋白名称:
C-X-C chemokine receptor type 3 (CXC-R3) (CXCR-3) (CKR-L2) (G protein-coupled receptor 9) (Interferon-inducible protein 10 receptor) (IP-10 receptor) (CD antigen CD183)
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别名:
CXCR3 ;
G protein-coupled receptor 9 ;
GPR9 ;
CKR-L2 ;
IP10 receptor ;
IP10-R ;
Mig receptor ;
Mig-R ;
C-X-C chemokine receptor type 3 antibody ;
CD 183 antibody ;
CD182 antibody ;
CD183 antibody ;
Chemokine ;
C X C motif ;
receptor 3 antibody ;
Chemokine ;
C X C ;
receptor 3 antibody ;
Chemokine CXC Motif Receptor 3 antibody ;
CKR L2 antibody ;
CKR-L2 antibody ;
CKRL2 antibody ;
CMKAR3 antibody ;
CXC-R3 antibody ;
CXCR-3 antibody ;
CXCR3 antibody ;
CXCR3_HUMAN antibody ;
G Protein Coupled Receptor 9 antibody ;
G protein-coupled receptor 9 antibody ;
GPR9 antibody ;
Interferon-inducible protein 10 receptor antibody ;
IP-10 receptor antibody ;
IP10 antibody ;
IP10 R antibody ;
IP10 receptor antibody ;
IP10-R antibody ;
IP10R antibody ;
Mig R antibody ;
Mig receptor antibody ;
Mig-R antibody ;
MIGR antibody ;
G protein-coupled receptor 9 ;
GPR9 ;
CKR-L2 ;
IP10 receptor ;
IP10-R ;
Mig receptor ;
Mig-R ;
C-X-C chemokine receptor type 3 antibody ;
CD 183 antibody ;
CD182 antibody ;
CD183 antibody ;
Chemokine ;
C X C motif ;
receptor 3 antibody ;
Chemokine ;
C X C ;
receptor 3 antibody ;
Chemokine CXC Motif Receptor 3 antibody ;
CKR L2 antibody ;
CKR-L2 antibody ;
CKRL2 antibody ;
CMKAR3 antibody ;
CXC-R3 antibody ;
CXCR-3 antibody ;
CXCR3 antibody ;
CXCR3_HUMAN antibody ;
G Protein Coupled Receptor 9 antibody ;
G protein-coupled receptor 9 antibody ;
GPR9 antibody ;
Interferon-inducible protein 10 receptor antibody ;
IP-10 receptor antibody ;
IP10 antibody ;
IP10 R antibody ;
IP10 receptor antibody ;
IP10-R antibody ;
IP10R antibody ;
Mig R antibody ;
Mig receptor antibody ;
Mig-R antibody ;
MIGR antibody ;
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背景:
CD183 , also known as CXCR3 , is a member of the C-X-C chemokine family , characterized by a pair of cysteine residues separated by a single amino acid. CXCR3 is a 38 kD seven pass transmembrane receptor coupled to G-protein. It mediates Ca2+ mobilization and chemotaxis in response to C-X-C chemokines , such as IP10 (CXCL10) , MIG (CXCL9) , I-TAC (CXCL11) and PF4 (CXCL4) . CXCR3 is expressed primarily on activiated T lymphocytes , NK cells , and some epithelial cells and endothelial cells. It is not expressed on B cells , monocytes , or granulocytes.
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功能:
Isoform 1 is a Receptor for CXCL9 , CXCL10 and CXCL11 and mediates the proliferation of human mesangial cells (HMC) .Isoform 2 is a receptor for CXCL4 and also mediates the inhibitory activities of CXCL9 , CXCL10 and CXCL11 on the growth of human microvascular endothelial cells (HMVEC) . May play a role in angiogenesis. Isoform 3 is mediates the activity of CXCL11.
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细胞定位:
[Isoform 1]: Cell membrane ; Multi-pass membrane protein .; [Isoform 2]: Cell membrane ; Multi-pass membrane protein .
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信号通路
Organismal Systems >> Immune system >> Chemokine signaling pathway
Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction
Environmental Information Processing >> Signaling molecules and interaction >> Viral protein interaction with cytokine and cytokine receptor
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