ADD2

Beta-adducin ;
Erythrocyte adducin subunit beta ;

alternative products:Additional isoforms seem to exist,developmental stage:Fetal kidney expresses isoforms 3, 4, 5, 6 and 7, and fetal liver expresses isoforms 3 and 4.,domain:Each subunit is comprised of three regions: a NH2-terminal protease-resistant globular head region, a short connecting subdomain, and a protease-sensitive tail region.,function:Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit.,PTM:The N-terminus is blocked.,similarity:Belongs to the aldolase class II family. Adducin subfamily.,subunit:Heterodimer of an alpha and a beta subunit.,tissue specificity:Expressed mainly in brain, spleen, kidney cortex and medulla, and heart. Also expressed in human umbilical vein endothelial cells, human vascular smooth muscle cells, kidney tubular cells and K562 cells.,

immune system development, ion transport, cytoskeleton organization, actin filament organization, regulation of actin polymerization or depolymerization, negative regulation of organelle organization, actin filament-based process, actin cytoskeleton organization, hemopoiesis, regulation of actin filament length, regulation of actin filament polymerization,regulation of actin filament depolymerization, negative regulation of actin filament depolymerization, negative regulation of actin filament polymerization, negative regulation of protein complex assembly, positive regulation of protein binding, regulation of protein polymerization, negative regulation of protein polymerization, regulation of cellular component size, regulation of actin cytoskeleton organization, regulation of actin filament-based process,regulation of organelle organization, negative regulation of protein complex disassembly, regulation of protein complex disassembly, regulation of protein complex assembly, regulation of protein binding, regulation of cellular component biogenesis, positive regulation of molecular function, hemopoietic or lymphoid organ development, barbed-end actin filament capping, actin filament bundle formation, regulation of binding, positive regulation of binding,negative regulation of cellular component organization, regulation of cytoskeleton organization, negative regulation of cytoskeleton organization, actin filament capping,

Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Expressed mainly in brain, spleen, kidney cortex and medulla, and heart. Also expressed in human umbilical vein endothelial cells, human vascular smooth muscle cells, kidney tubular cells and K-562 cell line.