YWHAZ

14-3-3 protein zeta/delta ;
Protein kinase C inhibitor protein 1 ;
KCIP-1 ;

caution:Was originally (PubMed:1577711) thought to have phospholipase A2 activity.,function:Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.,PTM:The delta, brain-specific form differs from the zeta form in being phosphorylated (By similarity). Phosphorylation on Ser-184 by MAPK8; promotes dissociation of BAX and translocation of BAX to mitochondria. Phosphorylation on Ser-58 by PKA; disrupts homodimerization and heterodimerization with YHAE and TP53. This phosphorylation appears to be activated by sphingosine. Phosphorylation on Thr-232; inhibits binding of RAF1.,similarity:Belongs to the 14-3-3 family.,subcellular location:Located to stage I to stage IV melanosomes.,subunit:Homodimer. Heterodimerizes with YWHAE. Homo- and hetero-dimerization is inhibited by phosphorylation on Ser-58. Interacts with FOXO4, NOXA1, SSH1 and ARHGEF2. Interacts with PCTK1 and BSPRY (By similarity). Interacts with WEE1 (C-terminal) (By similarity). Interacts with MLF1 (phosphorylated form); the interaction retains it in the cytoplasm (By similarity). Interacts with Thr-phosphorylated ITGB2 (By similarity). Interacts with Pseudomonas aeruginosa exoS (unphosphorylated form). Interacts with BAX; the interaction occurs in the cytoplasm. Under stress conditions, MAPK8-mediated phosphorylation releases BAX to mitochondria. Interacts with phosphorylated RAF1; the interaction is inhibited when YWHAZ is phosphorylated on Thr-232. Interacts with TP53; the interaction enhances p53 transcriptional acivity. The Ser-58 phosphorylated form inhibits this interaction and p53 transcriptional activity. Interacts with ABL1 (phosphorylated form); the interaction retains ABL1 in the cytoplasm. Interacts with AANAT ('Thr-31' phosphorylated form); the interaction modulates AANAT enzymatic activity through preventing dephosphorylation and/or proteolysis and stabilizing substrate binding. Subsequently, a second molecule of AANAT ('Ser-205' phosphorylated form), can bind the other YWHAZ monomer with similar effect. Interacts with AKT1; the interaction phosphorylates YWHAZ and modulates dimerization.,

cell activation, histamine secretion, immune effector process, cell activation during immune response, myeloid leukocyte activation, myeloid cell activation during immune response, histamine production during acute inflammatory response, leukocyte activation during immune response, histamine secretion during acute inflammatory response,leukocyte mediated immunity, myeloid leukocyte mediated immunity, mast cell mediated immunity, acute inflammatory response, production of molecular mediator of acute inflammatory response, histamine secretion by mast cell,generation of a signal involved in cell-cell signaling, protein targeting, protein targeting to mitochondrion,mitochondrial transport, intracellular protein transport, exocytosis, anti-apoptosis, defense response, inflammatory response, immune response, mitochondrion organization, cell-cell signaling, protein localization, response to wounding, hormone transport, regulation of hormone levels, regulation of cell death, protein transport, amine transport, vesicle-mediated transport, protein import, secretion by cell, protein localization in organelle, cellular protein localization, response to drug, regulation of apoptosis, negative regulation of apoptosis, regulation of programmed cell death, negative regulation of programmed cell death, leukocyte degranulation, mast cell degranulation, regulated secretory pathway, establishment of protein localization, leukocyte activation, mast cell activation, hormone secretion,secretion, intracellular transport, histamine transport, negative regulation of cell death, protein localization in mitochondrion, cellular macromolecule localization,

Cytoplasm . Melanosome . Located to stage I to stage IV melanosomes.