F2RL3

Proteinase-activated receptor 4 ;
PAR-4 ;
Coagulation factor II receptor-like 3 ;
Thrombin receptor-like 3 ;

function:Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation.,PTM:A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Widely expressed, with highest levels in lung, pancreas, thyroid, testis and small intestine. Not expressed in brain, kidney, spinal cord and peripheral blood leukocytes. Also detected in platelets.,

cell surface receptor linked signal transduction, G-protein coupled receptor protein signaling pathway, activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger,activation of phospholipase C activity, intracellular signaling cascade, blood coagulation, hemostasis, response to wounding, regulation of phospholipase activity, positive regulation of phospholipase activity, positive regulation of phospholipase C activity, second-messenger-mediated signaling, wound healing, positive regulation of catalytic activity, positive regulation of molecular function, phosphoinositide-mediated signaling, coagulation, regulation of body fluid levels, regulation of hydrolase activity, positive regulation of hydrolase activity, regulation of lipase activity,positive regulation of lipase activity,

Cell membrane; Multi-pass membrane protein.

Widely expressed, with highest levels in lung, pancreas, thyroid, testis and small intestine. Not expressed in brain, kidney, spinal cord and peripheral blood leukocytes. Also detected in platelets.