MMP12

Macrophage metalloelastase ;
MME ;
Macrophage elastase ;
ME ;
hME ;
Matrix metalloproteinase-12 ;
MMP-12 ;

catalytic activity:Hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in the B chain of insulin.,cofactor:Binds 2 zinc ions per subunit.,cofactor:Binds 4 calcium ions per subunit.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,function:May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.,induction:By exposure to lipopolysaccharide. Inhibited by dexamethasone.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 4 hemopexin-like domains.,tissue specificity:Found in alveolar macrophages but not in peripheral blood monocytes.,

proteolysis, positive regulation of cell proliferation, regulation of cell proliferation, response to drug, regulation of epithelial cell proliferation, positive regulation of epithelial cell proliferation,

Secreted, extracellular space, extracellular matrix .

Found in alveolar macrophages but not in peripheral blood monocytes.