CASP5

Caspase-5 ;
CASP-5 ;
ICE ;
rel ;
-III ;
Protease ICH-3 ;
Protease TY ;
[Cleaved into: Caspase-5 subunit p20 ;
Caspase-5 subunit p10]

catalytic activity:Strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|- but also cleaves at Asp-Glu-Val-Asp-|-.,function:Mediator of programmed cell death (apoptosis).,PTM:The two subunits are derived from the precursor sequence by an autocatalytic mechanism.,similarity:Belongs to the peptidase C14A family.,similarity:Contains 1 CARD domain.,subunit:Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 10 kDa (p10) subunits.,tissue specificity:Expressed in barely detectable amounts in most tissues except brain, highest levels being found in lung, liver and skeletal muscle.,

proteolysis, apoptosis, cell death, regulation of cell death, programmed cell death, death, regulation of apoptosis,regulation of programmed cell death,

Expressed in barely detectable amounts in most tissues except brain, highest levels being found in lung, liver and skeletal muscle.