CYP4F2

Leukotriene-B ;
4 ;
omega-hydroxylase 1 ;
CYPIVF2 ;
Cytochrome P450 4F2 ;
Cytochrome P450-LTB-omega ;
Leukotriene-B ;
4 ;
20-monooxygenase 1 ;

catalytic activity:(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + NADPH + O(2) = (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + NADP(+) + H(2)O.,cofactor:Heme group.,function:Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.,similarity:Belongs to the cytochrome P450 family.,tissue specificity:Liver.,

fatty acid metabolic process, icosanoid metabolic process, leukotriene metabolic process, unsaturated fatty acid metabolic process, cellular alkene metabolic process, oxidation reduction,

Microsome membrane ; Peripheral membrane protein . Endoplasmic reticulum membrane ; Peripheral membrane protein .

Liver. Also present in kidney: specifically expressed in the S2 and S3 segments of proximal tubules in cortex and outer medulla (PubMed:10660572).