CD159c (NKG2C) (PTF0127) Mouse mAb
-YF0108
主要信息
Target
NKG2C
Host Species
Mouse
Reactivity
Human
Applications
FC, IF
Conjugate/Modification
Unmodified
详细信息
推荐稀释比
IF 1:200-1:1000; FC:1 µg per million cells in 100 µl volume. For optimal results, the reagent should be titrated according to each specific application
组成
PBS, pH 7.4
特异性
Endogenous
纯化工艺
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
储存
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
浓度
0.5mg/ml
修饰
Unmodified
克隆性
Monoclonal
克隆号
PTF0127
同种型
Mouse IgG1/Kappa
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抗原&靶点信息
免疫原:
The specific immunogen used to produce this antibody is proprietary information.
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特异性:
Endogenous
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基因名称:
KLRC2 NKG2C
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蛋白名称:
NKG2-C type II integral membrane protein (CD159 antigen-like family member C) (NK cell receptor C) (NKG2-C-activating NK receptor) (CD antigen CD159c)
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背景:
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins , which have been implicated in the regulation of NK cell function. The group , designated KLRC (NKG2) are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family is located within the NK complex , a region that contains several C-type lectin genes preferentially expressed on NK cells. KLRC2 alternative splice variants have been described but their full-length nature has not been determined. [provided by RefSeq , Jul 2008] ,
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功能:
Function:Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. ,polymorphism:Two alleles are known. The sequence shown is that of allele NKG2-C*02. ,similarity:Contains 1 C-type lectin domain. ,subunit:Can form disulfide-bonded heterodimer with CD94. ,tissue specificity:Natural killer cells. ,
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细胞定位:
Cell membrane ; Single-pass type II membrane protein .
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研究领域:
>>Antigen processing and presentation ;
>>Natural killer cell mediated cytotoxicity
>>Natural killer cell mediated cytotoxicity
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