CYP24A1

1,25-dihydroxyvitamin D ;
3 ;
24-hydroxylase, mitochondrial ;
24-OHase ;
Vitamin D ;
3 ;
24-hydroxylase ;
Cytochrome P450 24A1 ;
Cytochrome P450-CC24 ;

catalytic activity:Calcidiol + NADPH + O(2) = secalciferol + NADP(+) + H(2)O.,catalytic activity:Calcitriol + NADPH + O(2) = calcitetrol + NADP(+) + H(2)O.,cofactor:Heme group.,function:Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25-hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23-hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product.,similarity:Belongs to the cytochrome P450 family.,

skeletal system development, ossification, osteoblast differentiation, steroid catabolic process, vitamin metabolic process, fat-soluble vitamin metabolic process, intracellular signaling cascade, response to nutrient, steroid metabolic process, vitamin catabolic process, response to extracellular stimulus, lipid catabolic process, intracellular receptor-mediated signaling pathway, response to nutrient levels, cellular response to extracellular stimulus, cellular response to nutrient levels, cellular response to nutrient, response to vitamin, response to vitamin D, vitamin D metabolic process, fat-soluble vitamin catabolic process, vitamin D catabolic process, oxidation reduction, bone development,vitamin D receptor signaling pathway,

Mitochondrion .