Total MEK Kinase-3 Cell-Based Colorimetric ELISA Kit
-KA3875C
主要信息
Reactivity
Human, Mouse
Applications
ELISA
Conjugate/Modification
Unmodified
详细信息
储存
2-8°C/6 months
修饰
Unmodified
检测方法
Colorimetric
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抗原&靶点信息
基因名称:
MAP3K3
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别名:
Mitogen-activated protein kinase kinase kinase 3 ;
MAPK/ERK kinase kinase 3 ;
MEK kinase 3 ;
MEKK 3 ;
MAPK/ERK kinase kinase 3 ;
MEK kinase 3 ;
MEKK 3 ;
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背景:
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation on Thr-530.,function:Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 OPR domain.,similarity:Contains 1 protein kinase domain.,subunit:Binds both upstream activators and downstream substrates in multimolecular complexes. Part of a complex with MAP2K3, RAC1 and CCM2. Interacts with MAP2K5 and SPAG9.,
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功能:
MAPKKK cascade, protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process,intracellular signaling cascade, protein kinase cascade, positive regulation of signal transduction, regulation of protein kinase cascade, positive regulation of cell communication, positive regulation of protein kinase cascade,phosphorylation, regulation of I-kappaB kinase/NF-kappaB cascade, positive regulation of I-kappaB kinase/NF-kappaB cascade, protein amino acid autophosphorylation,
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信号通路
Organismal Systems >> Endocrine system >> GnRH signaling pathway
Organismal Systems >> Nervous system >> Neurotrophin signaling pathway
Human Diseases >> Cancer: overview >> PD-L1 expression and PD-1 checkpoint pathway in cancer
Environmental Information Processing >> Signal transduction >> MAPK signaling pathway
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