DLC1

Rho GTPase-activating protein 7 ;
Deleted in liver cancer 1 protein ;
DLC-1 ;
HP protein ;
Rho-type GTPase-activating protein 7 ;
START domain-containing protein 12 ;
StARD12 ;
StAR-related lipid transfer protein 12 ;

function:Functions as a GTPase-activating protein specific for Rho and an activator of PLCD1 in vivo and induces morphological changes and detachment through cytoskeletal reorganization.,sequence caution:Chimera. Sequence from position 1 to 13 is due to a chimera.,similarity:Contains 1 Rho-GAP domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 1 START domain.,tissue specificity:Highest level of expression in the spleen, with rather lower levels in prostate, testis, ovary, small intestine and colon, but none in the thymus.,

embryonic epithelial tube formation, neural tube formation, neural tube closure, morphogenesis of an epithelium,heart morphogenesis, apoptosis, induction of apoptosis, activation of caspase activity, cytoskeleton organization, cell-substrate junction assembly, cell adhesion, cell-matrix adhesion, heart development, cell death, negative regulation of cell proliferation, regulation of cell shape, embryonic development ending in birth or egg hatching, negative regulation of signal transduction, positive regulation of phosphorus metabolic process, positive regulation of macromolecule metabolic process, negative regulation of organelle organization, negative regulation of cell communication, regulation of cell death, positive regulation of cell death, positive regulation of peptidase activity, programmed cell death,induction of programmed cell death, primary neural tube formation, death, morphogenesis of embryonic epithelium,regulation of phosphate metabolic process, hindbrain morphogenesis, neural tube development, regulation of cell morphogenesis, biological adhesion, actin filament-based process, actin cytoskeleton organization, regulation of cell migration, negative regulation of cell migration, forebrain development, hindbrain development, regulation of protein modification process, positive regulation of protein modification process, cell-substrate adhesion, regulation of actin filament bundle formation, negative regulation of actin filament bundle formation, regulation of cellular protein metabolic process, positive regulation of cellular protein metabolic process, regulation of actin cytoskeleton organization, regulation of actin filament-based process, regulation of organelle organization, cell junction assembly,cell junction organization, regulation of Rho protein signal transduction, negative regulation of Rho protein signal transduction, tube lumen formation, tube morphogenesis, tube development, regulation of dephosphorylation,regulation of protein amino acid dephosphorylation, positive regulation of dephosphorylation, positive regulation of protein amino acid dephosphorylation, regulation of locomotion, negative regulation of locomotion, regulation of cell proliferation, regulation of apoptosis, chordate embryonic development, positive regulation of apoptosis, regulation of programmed cell death, positive regulation of programmed cell death, positive regulation of catalytic activity, positive regulation of caspase activity, regulation of caspase activity, regulation of cellular component biogenesis, positive regulation of molecular function, positive regulation of phosphate metabolic process, regulation of Ras protein signal transduction, negative regulation of Ras protein signal transduction, focal adhesion formation, embryonic morphogenesis, tissue morphogenesis, regulation of small GTPase mediated signal transduction, negative regulation of small GTPase mediated signal transduction, negative regulation of cellular component organization, regulation of phosphorus metabolic process, positive regulation of protein metabolic process, regulation of cell motion, negative regulation of cell motion, regulation of hydrolase activity, positive regulation of hydrolase activity, regulation of stress fiber formation, regulation of cytoskeleton organization, negative regulation of cytoskeleton organization, negative regulation of stress fiber formation, regulation of peptidase activity, regulation of endopeptidase activity, epithelium development, epithelial tube morphogenesis, tube closure,

Cytoplasm. Cell junction, focal adhesion. Membrane; Peripheral membrane protein. Colocalizes with EF1A1 at actin-rich regions in the cell periphery.

Highest level of expression in the spleen, with rather lower levels in prostate, testis, ovary, small intestine and colon, but none in the thymus.