BRF1

Transcription factor IIIB 90 kDa subunit ;
TFIIIB90 ;
hTFIIIB90 ;
B-related factor 1 ;
BRF-1 ;
hBRF ;
TAF3B2 ;
TATA box-binding protein-associated factor, RNA polymerase III, subunit 2 ;

function:General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters. The isoform 1 is involved in the transcription of tRNA, adenovirus VA1, 7SL and 5S RNA. Isoform 2 is required for transcription of the U6 promoter.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the TFIIB family.,similarity:Contains 1 TFIIB-type zinc finger.,subunit:TFIIIB comprises at least the TATA-binding protein (TBP) and the B-related factor 1 (BRF1/TFIIIB90). Interacts with BDP1.,

transcription, transcription, DNA-dependent, transcription initiation, regulation of transcription, DNA-dependent,transcription from RNA polymerase III promoter, translation, translational initiation, protein complex assembly, rRNA transcription, tRNA transcription, positive regulation of biosynthetic process, positive regulation of macromolecule biosynthetic process, positive regulation of macromolecule metabolic process, posttranscriptional regulation of gene expression, positive regulation of gene expression, mRNA metabolic process, positive regulation of cellular biosynthetic process, RNA biosynthetic process, regulation of RNA stability, regulation of mRNA stability,macromolecular complex subunit organization, regulation of transcription, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of transcription, positive regulation of nitrogen compound metabolic process, regulation of RNA metabolic process, macromolecular complex assembly,protein complex biogenesis,

Nucleus .