FOXJ1

Forkhead box protein J1 ;
Forkhead-related protein FKHL13 ;
Hepatocyte nuclear factor 3 forkhead homolog 4 ;
HFH-4 ;

developmental stage:Expressed in developing lung, kidney and central nervous system.,disease:Genetic variations in FOXJ1 may be associated with susceptibility to allergic rhinitis (ALRH) [MIM:607154]. Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure.,function:May play an important role in cell fate determination during lung development and in spermatogenesis.,similarity:Contains 1 fork-head DNA-binding domain.,tissue specificity:Testis, oviduct, lung and brain cortex.,

negative regulation of transcription from RNA polymerase II promoter, cell morphogenesis, regulation of cytokine production, tolerance induction, central tolerance induction, immune system development, regulation of germinal center formation, negative regulation of germinal center formation, regulation of tolerance induction, positive regulation of tolerance induction, regulation of central tolerance induction, positive regulation of central tolerance induction, regulation of B cell tolerance induction, positive regulation of B cell tolerance induction, negative regulation of immune system process, positive regulation of immune system process, regulation of leukocyte activation, negative regulation of leukocyte activation, regulation of immune effector process, negative regulation of immune effector process, regulation of leukocyte mediated immunity, negative regulation of leukocyte mediated immunity, regulation of lymphocyte mediated immunity, negative regulation of lymphocyte mediated immunity, regulation of B cell mediated immunity, negative regulation of B cell mediated immunity, regulation of adaptive immune response, negative regulation of adaptive immune response, regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, regulation of immunoglobulin mediated immune response, negative regulation of immunoglobulin mediated immune response,regulation of central B cell tolerance induction, positive regulation of central B cell tolerance induction, regulation of humoral immune response, negative regulation of humoral immune response, regulation of humoral immune response mediated by circulating immunoglobulin, negative regulation of humoral immune response mediated by circulating immunoglobulin, transcription, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, cell motion, immune response, humoral immune response, cytoskeleton organization,establishment or maintenance of cell polarity, gamete generation, spermatogenesis, pattern specification process,negative regulation of cell proliferation, negative regulation of biosynthetic process, regulation of specific transcription from RNA polymerase II promoter, negative regulation of specific transcription from RNA polymerase II promoter,negative regulation of macromolecule biosynthetic process, negative regulation of macromolecule metabolic process,negative regulation of gene expression, cell migration, negative regulation of transcription, sexual reproduction,establishment of cell polarity, actin filament-based process, cell projection organization, cell projection assembly, actin cytoskeleton organization, negative regulation of cellular biosynthetic process, negative regulation of NF-kappaB transcription factor activity, regulation of Ras GTPase activity, regulation of Rho GTPase activity, positive regulation of Ras GTPase activity, positive regulation of Rho GTPase activity, multicellular organism reproduction, negative regulation of gene-specific transcription, regulation of gene-specific transcription, regulation of interleukin-6 production, activation of Ras GTPase activity, activation of Rho GTPase activity, regulation of mononuclear cell proliferation, negative regulation of mononuclear cell proliferation, cellular component morphogenesis, cell part morphogenesis, regulation of T cell differentiation in the thymus, negative regulation of T cell differentiation in the thymus, regulation of Rho protein signal transduction, establishment or maintenance of apical/basal cell polarity,establishment of apical/basal cell polarity, regulation of cytokine biosynthetic process, negative regulation of cytokine biosynthetic process, regulation of cell proliferation, regulation of T cell proliferation, negative regulation of T cell proliferation, cilium assembly, positive regulation of catalytic activity, regulation of GTPase activity, negative regulation of DNA binding, negative regulation of transcription factor activity, positive regulation of GTPase activity, negative regulation of molecular function, positive regulation of molecular function, regulation of interleukin-6 biosynthetic process, negative regulation of interleukin-6 biosynthetic process, regulation of transcription, regulation of T cell differentiation, negative regulation of T cell differentiation, negative regulation of cell differentiation, regulation of lymphocyte differentiation, negative regulation of lymphocyte differentiation, negative regulation of transcription, DNA-dependent, negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, regulation of Ras protein signal transduction, male gamete generation, negative regulation of response to stimulus, reproductive process in a multicellular organism, cell projection morphogenesis, cell motility, regulation of lymphocyte proliferation,negative regulation of lymphocyte proliferation, negative regulation of immune response, regulation of T cell activation, regulation of B cell activation, regulation of cell activation, negative regulation of cell activation, negative regulation of T cell activation, negative regulation of B cell activation, leukocyte migration, regulation of small GTPase mediated signal transduction, regulation of transcription factor activity, regulation of binding, negative regulation of binding, regulation of DNA binding, negative regulation of nitrogen compound metabolic process, regulation of lymphocyte activation, negative regulation of lymphocyte activation, regulation of RNA metabolic process, negative regulation of RNA metabolic process, regulation of hydrolase activity, positive regulation of hydrolase activity,localization of cell, cilium morphogenesis, regulation of leukocyte proliferation, negative regulation of leukocyte proliferation,

Nucleus .

Testis, oviduct, lung and brain cortex.