BRSK1

Serine/threonine-protein kinase BRSK1 ;
Brain-selective kinase 1 ;
Brain-specific serine/threonine-protein kinase 1 ;
BR serine/threonine-protein kinase 1 ;
Serine/threonine-protein kinase SAD-B ;
Synapses of Amphids Defective homolog 1 ;
SAD1 homolog ;
hSAD1 ;

catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation on Thr-205 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39.,function:Required for the polarization of forebrain neurons which endows axons and dendrites with distinct properties, possibly by locally regulating phosphorylation of microtubule-associated proteins (By similarity). May be involved in the regulation of G2/M arrest in response to UV- or methyl methane sulfonate (MMS)-induced, but not IR-induced, DNA damage. Phosphorylates WEE1 and CDC25B in vitro and CDC25C in vitro and in vivo.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 UBA domain.,subcellular location:Nuclear in the absence of DNA damage. Translocated to the nucleus in response to UV- or MMS-induced DNA damage.,tissue specificity:Widely expressed, with highest levels in brain and testis. Protein levels remain constant throughout the cell cycle.,

cell cycle checkpoint, DNA damage checkpoint, cell morphogenesis, protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, response to DNA damage stimulus, establishment or maintenance of cell polarity, intracellular signaling cascade, response to radiation, response to UV, response to light stimulus,response to abiotic stimulus, response to ionizing radiation, phosphorylation, establishment of cell polarity, neuron differentiation, DNA integrity checkpoint, G2/M transition DNA damage checkpoint, G2/M transition checkpoint, cellular component morphogenesis, cellular response to stress, DNA damage response, signal transduction, regulation of cell cycle,

Cytoplasm . Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cell junction, synapse . Cell junction, synapse, presynaptic active zone . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle . Nuclear in the absence of DNA damage. Translocated to the nucleus in response to UV- or MMS-induced DNA damage (By similarity). .

Widely expressed, with highest levels in brain and testis. Protein levels remain constant throughout the cell cycle.