Total Ksr2 Cell-Based Colorimetric ELISA Kit
-KA3796C
主要信息
Reactivity
Human, Mouse
Applications
ELISA
Conjugate/Modification
Unmodified
详细信息
储存
2-8°C/6 months
修饰
Unmodified
检测方法
Colorimetric
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抗原&靶点信息
基因名称:
KSR2
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别名:
Kinase suppressor of Ras 2 ;
hKSR2 ;
hKSR2 ;
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背景:
domain:The protein kinase domain is predicted to be catalytically inactive.,function:Location-regulated scaffold connecting MEK to RAF. Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.,PTM:Phosphorylated on Ser-474 by MARK3.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with MAP2K1, MAP3K8, MAPK, RAS and RAF.,tissue specificity:Mainly expressed in brain and kidney.,
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功能:
protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, intracellular signaling cascade, phosphorylation,
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细胞定位:
Cytoplasm . Membrane ; Peripheral membrane protein .
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组织表达:
Mainly expressed in brain and kidney.
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