MAST2

Microtubule-associated serine/threonine-protein kinase 2 ;

catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,function:Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation.,PTM:Phosphorylated and ubiquitinated. N-terminal ubiquitination leads to degradation of MAST2 by proteasome-mediated proteolysis. N-terminal phosphorylation appears to be a prerequisite for ubiquitination.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 PDZ (DHR) domain.,similarity:Contains 1 protein kinase domain.,subcellular location:Recruited to the sub-membranous area on interaction with PC-LKC.,tissue specificity:Abundant in the testis.,

regulation of cytokine production, reproductive developmental process, protein amino acid phosphorylation,phosphorus metabolic process, phosphate metabolic process, gamete generation, spermatogenesis, phosphorylation,sexual reproduction, multicellular organism reproduction, regulation of interleukin-12 production, regulation of cytokine biosynthetic process, regulation of interleukin-12 biosynthetic process, male gamete generation, spermatid differentiation, reproductive process in a multicellular organism, reproductive cellular process,

Cytoplasm, cytoskeleton . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Recruited to the sub-membranous area on interaction with CDHR2.

Abundant in the testis.