DGKD

Diacylglycerol kinase delta ;
DAG kinase delta ;
130 kDa diacylglycerol kinase ;
Diglyceride kinase delta ;
DGK-delta ;

catalytic activity:ATP + 1,2-diacylglycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.,enzyme regulation:Partially inhibited by phosphatidylserine.,function:May function as signaling molecule. Isoform 2 may be involved in cell growth and tumorigenesis.,PTM:Isoform 1 H domain is phosphorylated.,similarity:Belongs to the eukaryotic diacylglycerol kinase family.,similarity:Contains 1 DAGKc domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 2 phorbol-ester/DAG-type zinc fingers.,subunit:The two isoforms are able to form homo- and hetero-oligomer structures (at least tetramers).,tissue specificity:Isoform 2 is ubiquitously expressed also in tumor tissues. Isoform 1 is expressed in ovary, spleen and some tumor-derived cells.,

protein complex assembly, neutral lipid metabolic process, acylglycerol metabolic process, glycerol ether metabolic process, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway,transmembrane receptor protein tyrosine kinase signaling pathway, epidermal growth factor receptor signaling pathway, G-protein coupled receptor protein signaling pathway, activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway, intracellular signaling cascade, regulation of cell size, response to organic substance, cell growth, organic ether metabolic process, regulation of phosphate metabolic process, second-messenger-mediated signaling, activation of protein kinase activity, regulation of cellular component size, positive regulation of kinase activity, growth, regulation of phosphorylation, positive regulation of catalytic activity, regulation of kinase activity, macromolecular complex subunit organization, positive regulation of molecular function, regulation of protein kinase activity, positive regulation of protein kinase activity, diacylglycerol metabolic process, glycerolipid metabolic process, regulation of phosphorus metabolic process, protein oligomerization, protein homooligomerization,regulation of transferase activity, positive regulation of transferase activity, macromolecular complex assembly, protein complex biogenesis,

Membrane, clathrin-coated pit . Cytoplasm .; [Isoform 1]: Cell membrane ; Peripheral membrane protein . Cytoplasm . Isoform 1 translocation from cytoplasm to the plasma membrane is induced by phorbol esters (PubMed:12200442). Phorbol esters induce the conversion into the monomeric form which can translocate to the plasma membrane (PubMed:12084710). .

[Isoform 2]: Widely expressed. ; [Isoform 1]: Only detected in ovary, and to a lesser extent in spleen.