CDKN3

Cyclin-dependent kinase inhibitor 3 ;
EC 3.1.3.48 ;
CDK2-associated dual-specificity phosphatase ;
Cyclin-dependent kinase interactor 1 ;
Cyclin-dependent kinase-interacting protein 2 ;
Kinase-associated phosphatase ;

catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,disease:Defects in CDKN3 are found in patients with hepatocellular carcinoma (HCC) [MIM:114550].,function:May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner.,induction:Up-regulated in breast and prostate cancer cells.,similarity:Belongs to the protein-tyrosine phosphatase family.,subunit:Interacts with cyclin-dependent kinases such as CDC2, CDK2 and CDK3. Does not interact with CDK4. Interacts (via C-terminus) with phosphorylated CDK2 (via C-terminal helix). Interacts with MS4A3 (via C-terminus); the interaction enhances CDKN3 enzymatic activity.,

regulation of cyclin-dependent protein kinase activity, G1/S transition of mitotic cell cycle, mitotic cell cycle, phosphorus metabolic process, phosphate metabolic process, cell cycle, cell cycle arrest, negative regulation of cell proliferation,dephosphorylation, regulation of phosphate metabolic process, cell cycle process, cell cycle phase, regulation of cell proliferation, regulation of phosphorylation, regulation of kinase activity, regulation of protein kinase activity,regulation of phosphorus metabolic process, interphase, interphase of mitotic cell cycle, regulation of transferase activity, regulation of cell cycle,

Cytoplasm, perinuclear region .