RPS6KA2

Ribosomal protein S6 kinase alpha-2 ;
S6K-alpha-2 ;
90 kDa ribosomal protein S6 kinase 2 ;
p90-RSK 2 ;
p90RSK2 ;
MAP kinase-activated protein kinase 1c ;
MAPK-activated protein kinase 1c ;
MAPKAP kinase 1c ;
MAPKAPK-1c ;
Ribosomal S6 kinase 3 ;
RSK-3 ;
pp90RSK3 ;

catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by multiple phosphorylations on threonine and serine residues.,function:Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.,PTM:Autophosphorylated on Ser-377, as part of the activation process.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 2 protein kinase domains.,subunit:Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation.,tissue specificity:Expressed in many tissues. Highest expression in lung and skeletal muscle.,

protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, intracellular signaling cascade, protein kinase cascade, phosphorylation,

Nucleus . Cytoplasm .

Widely expressed with higher expression in lung, skeletal muscle, brain, uterus, ovary, thyroid and prostate.