IRF4

Interferon regulatory factor 4 ;
IRF-4 ;
Lymphocyte-specific interferon regulatory factor ;
LSIRF ;
Multiple myeloma oncogene 1 ;
NF-EM5 ;

disease:A chromosomal aberration involving IRF4 may be a cause of multiple myeloma [MIM:254500]. Translocation t(6;14)(p25;q32) with the IgH locus.,function:Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells.,induction:Not induced by interferons.,similarity:Belongs to the IRF family.,similarity:Contains 1 tryptophan pentad repeat DNA-binding domain.,subunit:Interacts with SPIB and DEF6.,tissue specificity:Lymphoid cells.,

myeloid dendritic cell activation, cell activation, regulation of cytokine production, myeloid leukocyte activation, immune system development, leukocyte differentiation, myeloid leukocyte differentiation, regulation of leukocyte activation,chromatin organization, transcription, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, protein amino acid acetylation, positive regulation of biosynthetic process, regulation of specific transcription from RNA polymerase II promoter, positive regulation of specific transcription from RNA polymerase II promoter, positive regulation of macromolecule biosynthetic process, positive regulation of macromolecule metabolic process, positive regulation of gene expression, chromatin modification, covalent chromatin modification, histone modification, histone acetylation, hemopoiesis, myeloid cell differentiation, positive regulation of cellular biosynthetic process, regulation of gene-specific transcription, regulation of interleukin-10 production,regulation of interleukin-13 production, regulation of interleukin-2 production, regulation of interleukin-4 production,regulation of cytokine biosynthetic process, positive regulation of cytokine biosynthetic process, T cell activation,myeloid dendritic cell differentiation, positive regulation of gene-specific transcription, regulation of CD4-positive, alpha beta T cell differentiation, positive regulation of DNA binding, protein amino acid acylation, histone H3 acetylation,histone H4 acetylation, positive regulation of molecular function, regulation of interleukin-10 biosynthetic process,regulation of interleukin-2 biosynthetic process, positive regulation of interleukin-10 biosynthetic process, positive regulation of interleukin-2 biosynthetic process, leukocyte activation, regulation of interleukin-13 biosynthetic process,positive regulation of interleukin-13 biosynthetic process, regulation of interleukin-4 biosynthetic process, positive regulation of interleukin-4 biosynthetic process, regulation of transcription, regulation of T cell differentiation,regulation of lymphocyte differentiation, regulation of T-helper cell differentiation, positive regulation of transcription, DNA-dependent, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of transcription, positive regulation of transcription from RNA polymerase II promoter, regulation of alpha-beta T cell activation, regulation of alpha-beta T cell differentiation, lymphocyte activation, hemopoietic or lymphoid organ development, regulation of T cell activation, regulation of cell activation, regulation of binding, positive regulation of binding, regulation of DNA binding, positive regulation of nitrogen compound metabolic process,regulation of lymphocyte activation, regulation of RNA metabolic process, positive regulation of RNA metabolic process,chromosome organization,

Nucleus.

Lymphoid cells.