Total WTAP Cell-Based Colorimetric ELISA Kit
-KA3739C
主要信息
Reactivity
Human, Mouse
Applications
ELISA
Conjugate/Modification
Unmodified
详细信息
储存
2-8°C/6 months
修饰
Unmodified
检测方法
Colorimetric
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抗原&靶点信息
基因名称:
WTAP
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别名:
Pre-mRNA-splicing regulator WTAP ;
Female-lethal ;
2 ;
D homolog ;
hFL ;
2 ;
D ;
WT1-associated protein ;
Wilms tumor 1-associating protein ;
Female-lethal ;
2 ;
D homolog ;
hFL ;
2 ;
D ;
WT1-associated protein ;
Wilms tumor 1-associating protein ;
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背景:
function:Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability. Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes. May be involved in mRNA splicing regulation.,induction:In smooth muscle cells, up-regulated after serum withdrawal, when cells become mature and non proliferative.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the fl(2)d family.,subunit:Interacts with WT1.,tissue specificity:Ubiquitously expressed.,
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功能:
RNA processing, mRNA processing, cell cycle, RNA splicing, mRNA metabolic process,
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细胞定位:
Nucleus speckle . Nucleus, nucleoplasm . Cytoplasm . Mainly nuclear with some fraction located in the cytoplasm. ZC3H13 is required to anchor component of the MACOM subcomplex, such as VIRMA, in the nucleus. .
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组织表达:
Ubiquitously expressed.
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