Total Mi2-β Cell-Based Colorimetric ELISA Kit
-KA3735C
主要信息
Reactivity
Human, Mouse
Applications
ELISA
Conjugate/Modification
Unmodified
详细信息
储存
2-8°C/6 months
修饰
Unmodified
检测方法
Colorimetric
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Total Mi2-β Cell-Based Colorimetric ELISA Kit
KA3735C
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抗原&靶点信息
基因名称:
CHD4
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别名:
Chromodomain-helicase-DNA-binding protein 4 ;
CHD-4 ;
ATP-dependent helicase CHD4 ;
Mi-2 autoantigen 218 kDa protein ;
Mi2-beta ;
CHD-4 ;
ATP-dependent helicase CHD4 ;
Mi-2 autoantigen 218 kDa protein ;
Mi2-beta ;
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背景:
disease:One of the main antigens reacting with anti-MI-2 positive sera of dermatomyositis.,function:Probable transcription regulator.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the SNF2/RAD54 helicase family.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 1 helicase C-terminal domain.,similarity:Contains 2 chromo domains.,similarity:Contains 2 PHD-type zinc fingers.,subunit:Central component of the nucleosome remodeling and histone deacetylase (NuRD) repressor complex. Interacts with TRIM27. Part of a complex containing ATR and HDAC2. Interacts with KLF1; the interaction depends on sumoylation of KLF1, and leads to its transcriptional repression.,
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功能:
chromatin organization, chromatin assembly or disassembly, transcription, regulation of transcription, DNA-dependent,regulation of transcription from RNA polymerase II promoter, chromatin modification, regulation of transcription,regulation of RNA metabolic process, chromosome organization,
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细胞定位:
Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Associates with centrosomes in interphase. .
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