MELK

Maternal embryonic leucine zipper kinase ;
hMELK ;
Protein kinase Eg3 ;
pEg3 kinase ;
Protein kinase PK38 ;
hPK38 ;
Tyrosine-protein kinase MELK ;

catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Phosphorylates ZNF622 and may contribute to its redirection to the nucleus. May be involved in the inhibition of spliceosome assembly during mitosis.,PTM:Autophosphorylated. Thr-478 phosphorylation during mitosis promotes interaction with PPP1R8.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.,similarity:Contains 1 KA1 (kinase-associated) domain.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with ZNF622 and PPP1R8.,tissue specificity:Expressed in placenta, kidney, thymus, testis, ovary and intestine.,

protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, phosphorylation,

Cell membrane ; Peripheral membrane protein .

Expressed in placenta, kidney, thymus, testis, ovary and intestine.