MECOM

MDS1 and EVI1 complex locus protein MDS1 ;
Myelodysplasia syndrome 1 protein ;
Myelodysplasia syndrome-associated protein 1 ;

disease:A chromosomal aberration involving EVI1 is a cause of chronic myelogenous leukemia (CML). Translocation t(3;21)(q26;q22) with RUNX1/AML1.,disease:A chromosomal aberration involving MDS1 is found in a form of acute myeloid leukemia (AML). Translocation t(3;21) with AML1.,miscellaneous:Can be produced either as a separate transcript and as a normal fusion transcript with EVI1.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 10 C2H2-type zinc fingers.,subunit:May interact with CTBP1.,

in utero embryonic development, leukocyte homeostasis, neutrophil homeostasis, myeloid cell homeostasis, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, defense response,inflammatory response, heart development, response to wounding, response to bacterium, post-embryonic development, embryonic development ending in birth or egg hatching, positive regulation of biosynthetic process,positive regulation of macromolecule biosynthetic process, positive regulation of macromolecule metabolic process,positive regulation of gene expression, embryonic limb morphogenesis, forebrain development, positive regulation of cellular biosynthetic process, appendage morphogenesis, limb morphogenesis, embryonic appendage morphogenesis,embryonic forelimb morphogenesis, embryonic hindlimb morphogenesis, forelimb morphogenesis, hindlimb morphogenesis, regulation of cell proliferation, homeostatic process, chordate embryonic development, regulation of transcription, positive regulation of transcription, DNA-dependent, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of transcription, positive regulation of transcription from RNA polymerase II promoter, embryonic morphogenesis, appendage development, homeostasis of number of cells, positive regulation of nitrogen compound metabolic process, regulation of RNA metabolic process, positive regulation of RNA metabolic process, pericardium development, limb development, epithelium development,