PSMD2

26S proteasome non-ATPase regulatory subunit 2 ;
26S proteasome regulatory subunit RPN1 ;
26S proteasome regulatory subunit S2 ;
26S proteasome subunit p97 ;
Protein 55.11 ;
Tumor necrosis factor type 1 receptor-associated protein 2 ;

function:Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.,function:Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.,similarity:Belongs to the proteasome subunit S2 family.,similarity:Contains 7 PC repeats.,tissue specificity:Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung and placenta.,

mitotic cell cycle, proteolysis, ubiquitin-dependent protein catabolic process, cell cycle, macromolecule catabolic process, regulation of catabolic process, proteasomal protein catabolic process, positive regulation of macromolecule metabolic process, negative regulation of macromolecule metabolic process, modification-dependent protein catabolic process, cell cycle process, protein catabolic process, anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, regulation of protein ubiquitination, negative regulation of protein ubiquitination,positive regulation of protein ubiquitination, regulation of protein modification process, negative regulation of protein modification process, positive regulation of protein modification process, regulation of cellular protein metabolic process, negative regulation of cellular protein metabolic process, positive regulation of cellular protein metabolic process, regulation of protein catabolic process, positive regulation of catalytic activity, negative regulation of catalytic activity, proteasomal ubiquitin-dependent protein catabolic process, modification-dependent macromolecule catabolic process, negative regulation of molecular function, positive regulation of molecular function, cellular protein catabolic process, cellular macromolecule catabolic process, positive regulation of protein metabolic process, negative regulation of protein metabolic process, regulation of ligase activity, positive regulation of ligase activity, negative regulation of ligase activity, negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle, positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle, regulation of ubiquitin-protein ligase activity, regulation of ubiquitin-protein ligase activity during mitotic cell cycle, positive regulation of ubiquitin-protein ligase activity, negative regulation of ubiquitin-protein ligase activity, proteolysis involved in cellular protein catabolic process,

Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung and placenta.